Enhanced serum cortisol response to 5-hydroxytryptophan in depression and mania

H. Y. Meltzer*, B. Uberkoman-Witta, A. Robertson, B. J. Tricou, M. Lowy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The serum cortisol responses to D, L-5-hydroxytryptophan (5-HTP), 200 mg per oral, in unmedicated depressed and manic patients, were both significantly greater than that of normal controls. The cortisol response to 5-HTP in depressed patients was significantly correlated with ratings of specific symptoms of depression. It was also greater in non-psychotic than in psychotic depressed patients as well as in those manic or depressed patients who attempted suicide compared to those who had not. In view of evidence for decreased brain serotonergic activity in depression and perhaps mania, the results suggest at least some serotonin receptors may be supersensitive in some patients with affective disorders.

Original languageEnglish (US)
Pages (from-to)2541-2549
Number of pages9
JournalLife Sciences
Issue number25
StatePublished - Dec 19 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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