Enhanced serum cortisol response to 5-hydroxytryptophan in depression and mania

H. Y. Meltzer; B. Uberkoman-Witta; A. Robertson; B. J. Tricou; M. Lowy

doi:10.1016/0024-3205(83)90164-9

Enhanced serum cortisol response to 5-hydroxytryptophan in depression and mania

H. Y. Meltzer^*, B. Uberkoman-Witta, A. Robertson, B. J. Tricou, M. Lowy

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The serum cortisol responses to D, L-5-hydroxytryptophan (5-HTP), 200 mg per oral, in unmedicated depressed and manic patients, were both significantly greater than that of normal controls. The cortisol response to 5-HTP in depressed patients was significantly correlated with ratings of specific symptoms of depression. It was also greater in non-psychotic than in psychotic depressed patients as well as in those manic or depressed patients who attempted suicide compared to those who had not. In view of evidence for decreased brain serotonergic activity in depression and perhaps mania, the results suggest at least some serotonin receptors may be supersensitive in some patients with affective disorders.

Original language	English (US)
Pages (from-to)	2541-2549
Number of pages	9
Journal	Life Sciences
Volume	33
Issue number	25
DOIs	https://doi.org/10.1016/0024-3205(83)90164-9
State	Published - Dec 19 1983

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0024-3205(83)90164-9

Cite this

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title = "Enhanced serum cortisol response to 5-hydroxytryptophan in depression and mania",

abstract = "The serum cortisol responses to D, L-5-hydroxytryptophan (5-HTP), 200 mg per oral, in unmedicated depressed and manic patients, were both significantly greater than that of normal controls. The cortisol response to 5-HTP in depressed patients was significantly correlated with ratings of specific symptoms of depression. It was also greater in non-psychotic than in psychotic depressed patients as well as in those manic or depressed patients who attempted suicide compared to those who had not. In view of evidence for decreased brain serotonergic activity in depression and perhaps mania, the results suggest at least some serotonin receptors may be supersensitive in some patients with affective disorders.",

author = "Meltzer, {H. Y.} and B. Uberkoman-Witta and A. Robertson and Tricou, {B. J.} and M. Lowy",

note = "Funding Information: We wish to acknowledge the assistant of Mrs. Vaile Lopez, Mr. Dennis Joy and Nell Barnett in the catheter studies. Supported, in part, by the Department of Mental Health, State of ~llinois and by USPHS MH 30059 and MH 25116. HYM is recipient of USPHS Research Career Scientist Award MH 47808.",

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AU - Meltzer, H. Y.

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AU - Robertson, A.

AU - Tricou, B. J.

AU - Lowy, M.

N1 - Funding Information: We wish to acknowledge the assistant of Mrs. Vaile Lopez, Mr. Dennis Joy and Nell Barnett in the catheter studies. Supported, in part, by the Department of Mental Health, State of ~llinois and by USPHS MH 30059 and MH 25116. HYM is recipient of USPHS Research Career Scientist Award MH 47808.

PY - 1983/12/19

Y1 - 1983/12/19

N2 - The serum cortisol responses to D, L-5-hydroxytryptophan (5-HTP), 200 mg per oral, in unmedicated depressed and manic patients, were both significantly greater than that of normal controls. The cortisol response to 5-HTP in depressed patients was significantly correlated with ratings of specific symptoms of depression. It was also greater in non-psychotic than in psychotic depressed patients as well as in those manic or depressed patients who attempted suicide compared to those who had not. In view of evidence for decreased brain serotonergic activity in depression and perhaps mania, the results suggest at least some serotonin receptors may be supersensitive in some patients with affective disorders.

AB - The serum cortisol responses to D, L-5-hydroxytryptophan (5-HTP), 200 mg per oral, in unmedicated depressed and manic patients, were both significantly greater than that of normal controls. The cortisol response to 5-HTP in depressed patients was significantly correlated with ratings of specific symptoms of depression. It was also greater in non-psychotic than in psychotic depressed patients as well as in those manic or depressed patients who attempted suicide compared to those who had not. In view of evidence for decreased brain serotonergic activity in depression and perhaps mania, the results suggest at least some serotonin receptors may be supersensitive in some patients with affective disorders.

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Enhanced serum cortisol response to 5-hydroxytryptophan in depression and mania

Abstract

ASJC Scopus subject areas

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