Enhanced susceptibility to Theiler's virus-induced demyelinating disease in perforin-deficient mice

Joann P. Palma, Hee Gu Lee, Mani Mohindru, Bong Su Kang, Mauro Dal Canto, Stephen D. Miller, Byung S. Kim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Theiler's virus induces immune-mediated demyelinating disease similar to human MS in susceptible mice. Though the MHC class II-restricted T cell response is critical, susceptibility/resistance is also associated with a MHC class I haplotype. Here we report that perforin-deficient C57BL/6 mice (pKO) are susceptible to demyelination and develop clinical disease. The levels of primary demyelination, proliferation, Th1 responses, and viral load were also markedly enhanced. In addition, immunization of pKO mice with UV-inactivated virus further enhanced clinical incidence and accelerated the disease course. Thus, perforin is most likely involved in viral clearance, hence protection from the disease.

Original languageEnglish (US)
Pages (from-to)125-135
Number of pages11
JournalJournal of Neuroimmunology
Volume116
Issue number2
DOIs
StatePublished - Jun 1 2001

Keywords

  • CTL
  • Infectious immunity
  • Neuroimmunology
  • Virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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