Enhancement and destruction of antibody function by somatic mutation: Unequal occurrence is controlled by V gene combinatorial associations

Keyphrases

• Affinity Maturation 66%
• Antibody Function 100%
• Antigen Binding 66%
• Antigen-binding Site 33%
• B Cells 33%
• Binding Capacity 33%
• Binding Site Flexibility 33%
• Carrier Protein 33%
• Complementarity-determining Region 3 (CDR3) 33%
• Gene Sequencing 33%
• Germ Cells 33%
• In Vitro mutagenesis 33%
• Long-range Effect 33%
• Loss Function 33%
• Memory Response 66%
• Molecular Modeling 33%
• Negative Effects 33%
• Phosphatidylcholine 33%
• Point mutation 33%
• Primary Response 33%
• Rational Design 33%
• Saturation mutagenesis 33%
• Somatic mutation 100%
• V Genes 100%
• Wastage 33%

Biochemistry, Genetics and Molecular Biology

• Antibody Combining Site 33%
• Antigen Binding 66%
• B Cell 33%
• Binding Site 33%
• Carrier Protein 33%
• Complementarity Determining Region 33%
• Gene Sequence 33%
• Germ Cell 33%
• Germline 33%
• Maturation 66%
• Mitochondrial Membrane Transport Protein 33%
• Molecular Model 33%
• Mutagenesis 33%
• Phosphorylcholine 33%
• Point Mutation 33%
• Somatic Mutation 100%

Immunology and Microbiology

• Affinity Maturation 66%
• B Cell 33%
• Binding Antibody 66%
• Binding Site 33%
• Complementarity Determining Region 33%
• Gene Sequence 33%
• Germ Cell 33%
• Membrane Transport Protein 33%
• Molecular Model 33%
• Mutagenesis 33%
• Paratope 33%
• Point Mutation 33%
• Somatic Mutation 100%