Enhancement by wy-14,643, a hepatic peroxisome proliferator, of diethylnitrosamine-initiated hepatic tumorigenesis in the rat

J. K. Reddy, M. S. Rao

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Diethylnitrosamine (DEN), at a concentration of 100 parts/106 in drinking water for 14 days, caused the development, by 48 weeks, of very few liver tumours in 5 of 18 (27%) male F-344 rats fed control diet. When the DEN treatment was followed one week later by continuous feeding of the hypolipidemic hepatic peroxisome pro-liferator, Wy-14,643, at 01% dietary level, all of 28 rats (100%) developed, between 38 and 48 weeks, a significantly higher number of liver tumours. Furthermore, laparotomy at 22 weeks revealed that several rats fed Wy-14,643 after DEN initiation had developed visible liver nodules, suggesting that Wy-14,643 also accelerates the appearance of these tumours. Administration of another peroxisome proliferator, clofibrate, at 0·5% level in the diet after DEN initiation, also caused a substantial enhancement of liver tumorigenesis. The enhancement of liver-tumour development by clofibrate, however, was less than that by Wy-14,643. The marked enhancing effect of Wy-14,643 may be due to its profound hepatomegalic and peroxisome pro-liferative properties.

Original languageEnglish (US)
Pages (from-to)537-543
Number of pages7
JournalBritish Journal of Cancer
Volume38
Issue number4
DOIs
StatePublished - Oct 1978

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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