Abstract
Objective: The goal of this study was to evaluate the effects of the addition of tandospirone, a serotonin-1A (5-HT1A) agonist, to ongoing treatment with typical antipsychotic drugs, on two cognitive domains that are relevant to functional outcome in patients with schizophrenia. Method: Twenty-six patients with schizophrenia who were receiving stable doses of typical antipsychotics were randomly assigned to adjunctive treatment with 30 mg/day of tandospirone or placebo for 6 weeks. Executive function and verbal memory as well as psychopathology were assessed at baseline and after 6 weeks. Results: Both cognitive measures improved significantly in the patients who received tandospirone; subjects who did not receive tandospirone showed no change. There was no significant change in psychopathology ratings in either group. Conclusions: The results suggest the usefulness of 5-HT1A agonists for enhancing some types of cognitive performance and possibly social and work function in patients with schizophrenia.
Original language | English (US) |
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Pages (from-to) | 1722-1725 |
Number of pages | 4 |
Journal | American Journal of Psychiatry |
Volume | 158 |
Issue number | 10 |
DOIs | |
State | Published - 2001 |
ASJC Scopus subject areas
- Psychiatry and Mental health