Enhancer biology and enhanceropathies

Edwin Smith, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview article

135 Scopus citations

Abstract

Enhancers are cis-regulatory elements that enable precise spatiotemporal patterns of gene expression during development and are notable for being able to function at large distances from their target genes. Such regulatory elements often bypass intervening genes and typically comprise binding sites for multiple transcription factors that can also be transcribed by RNA polymerase II (Pol II) to produce noncoding enhancer RNAs (eRNAs). Genome-wide analyses have revealed chromatin signatures of enhancers, such as the enrichment for monomethylation of histone H3 lysine 4 (H3K4me1) and the acetylation or methylation of histone H3 lysine 27 (H3K27). Enhancer signatures have been used to describe the transitions of these regulatory elements from inactive to primed and from activated to decommissioned states during development. New mutations of enhancer sequences and of the protein factors regulating enhancer function in human disease continue to be identified, contributing to a growing class of 'enhanceropathies'.

Original languageEnglish (US)
Pages (from-to)210-219
Number of pages10
JournalNature Structural and Molecular Biology
Volume21
Issue number3
DOIs
StatePublished - Mar 2014

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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