Enhancer RNAs are an important regulatory layer of the epigenome

Vittorio Sartorelli, Shannon M. Lauberth*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

216 Scopus citations

Abstract

Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing and translation. Leading the charge in the RNA revolution is a class of ncRNAs that are synthesized at active enhancers, called enhancer RNAs (eRNAs). Here, we review recent insights into the biogenesis of eRNAs and the mechanisms underlying their multifaceted functions and consider how these findings could inform future investigations into enhancer transcription and eRNA function.

Original languageEnglish (US)
Pages (from-to)521-528
Number of pages8
JournalNature Structural and Molecular Biology
Volume27
Issue number6
DOIs
StatePublished - Jun 1 2020

Funding

We thank Jim Kadonaga for reading the manuscript and providing helpful suggestions. Research in the Lauberth laboratory is supported by a grant from the NIH/National Institute of General Medical Sciences (R35 GM128900) to S.L., and research in the Sartorelli laboratory is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases Intramural Research Program of the NIH (grants AR041126 and AR041164).

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Fingerprint

Dive into the research topics of 'Enhancer RNAs are an important regulatory layer of the epigenome'. Together they form a unique fingerprint.

Cite this