Enhancer RNAs are an important regulatory layer of the epigenome

Vittorio Sartorelli, Shannon M. Lauberth*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

91 Scopus citations

Abstract

Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing and translation. Leading the charge in the RNA revolution is a class of ncRNAs that are synthesized at active enhancers, called enhancer RNAs (eRNAs). Here, we review recent insights into the biogenesis of eRNAs and the mechanisms underlying their multifaceted functions and consider how these findings could inform future investigations into enhancer transcription and eRNA function.

Original languageEnglish (US)
Pages (from-to)521-528
Number of pages8
JournalNature Structural and Molecular Biology
Volume27
Issue number6
DOIs
StatePublished - Jun 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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