Enriched housing masks deficits in place navigation induced by neonatal monosodium glutamate

Matti J. Saari; Shirley Fong; Amin Shivji; John N. Armstrong

doi:10.1016/0892-0362(90)90109-P

Enriched housing masks deficits in place navigation induced by neonatal monosodium glutamate

Matti J. Saari^*, Shirley Fong, Amin Shivji, John N. Armstrong

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Monosodium-L-glutamate (MSG)-induced behavioural deficits were examined under two housing conditions. Male Wistar rat pups were cross-fostered at birth and injected with MSG on days 2 to 11 postpartum. Control pups were injected with saline (Sal) of equivalent volume. Following weaning at day 25 the rats were allocated to either "enriched" (EC) or "impoverished" (IC) housing, thus forming four treatment groups: MSG-EC, MSG-IC, Sal-EC, and Sal-IC. Thirty-five days later all rats were tested in the open field and in the place navigation task. Multivariate analysis of variance (MANOVA) revealed a significant two-way interaction of the housing × drug variables. While the MSG-IC rats were deficient in the water maze, the performance of the MSG-EC approached that of saline-injected controls. Although the Sal-IC rats developed higher body weights than the Sal-EC rats the MSG-EC and MSG-IC rats did not differ in body weight. The housing by drug treatment interaction was not apparent in the open field.

Original language	English (US)
Pages (from-to)	29-32
Number of pages	4
Journal	Neurotoxicology and Teratology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/0892-0362(90)90109-P
State	Published - 1990
Externally published	Yes

Keywords

Housing environment
MSG toxicity
Neonatal administration
Place navigation task

ASJC Scopus subject areas

Toxicology
Developmental Neuroscience
Cellular and Molecular Neuroscience

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title = "Enriched housing masks deficits in place navigation induced by neonatal monosodium glutamate",

abstract = "Monosodium-L-glutamate (MSG)-induced behavioural deficits were examined under two housing conditions. Male Wistar rat pups were cross-fostered at birth and injected with MSG on days 2 to 11 postpartum. Control pups were injected with saline (Sal) of equivalent volume. Following weaning at day 25 the rats were allocated to either {"}enriched{"} (EC) or {"}impoverished{"} (IC) housing, thus forming four treatment groups: MSG-EC, MSG-IC, Sal-EC, and Sal-IC. Thirty-five days later all rats were tested in the open field and in the place navigation task. Multivariate analysis of variance (MANOVA) revealed a significant two-way interaction of the housing × drug variables. While the MSG-IC rats were deficient in the water maze, the performance of the MSG-EC approached that of saline-injected controls. Although the Sal-IC rats developed higher body weights than the Sal-EC rats the MSG-EC and MSG-IC rats did not differ in body weight. The housing by drug treatment interaction was not apparent in the open field.",

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year = "1990",

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AU - Saari, Matti J.

AU - Fong, Shirley

AU - Shivji, Amin

AU - Armstrong, John N.

PY - 1990

Y1 - 1990

N2 - Monosodium-L-glutamate (MSG)-induced behavioural deficits were examined under two housing conditions. Male Wistar rat pups were cross-fostered at birth and injected with MSG on days 2 to 11 postpartum. Control pups were injected with saline (Sal) of equivalent volume. Following weaning at day 25 the rats were allocated to either "enriched" (EC) or "impoverished" (IC) housing, thus forming four treatment groups: MSG-EC, MSG-IC, Sal-EC, and Sal-IC. Thirty-five days later all rats were tested in the open field and in the place navigation task. Multivariate analysis of variance (MANOVA) revealed a significant two-way interaction of the housing × drug variables. While the MSG-IC rats were deficient in the water maze, the performance of the MSG-EC approached that of saline-injected controls. Although the Sal-IC rats developed higher body weights than the Sal-EC rats the MSG-EC and MSG-IC rats did not differ in body weight. The housing by drug treatment interaction was not apparent in the open field.

AB - Monosodium-L-glutamate (MSG)-induced behavioural deficits were examined under two housing conditions. Male Wistar rat pups were cross-fostered at birth and injected with MSG on days 2 to 11 postpartum. Control pups were injected with saline (Sal) of equivalent volume. Following weaning at day 25 the rats were allocated to either "enriched" (EC) or "impoverished" (IC) housing, thus forming four treatment groups: MSG-EC, MSG-IC, Sal-EC, and Sal-IC. Thirty-five days later all rats were tested in the open field and in the place navigation task. Multivariate analysis of variance (MANOVA) revealed a significant two-way interaction of the housing × drug variables. While the MSG-IC rats were deficient in the water maze, the performance of the MSG-EC approached that of saline-injected controls. Although the Sal-IC rats developed higher body weights than the Sal-EC rats the MSG-EC and MSG-IC rats did not differ in body weight. The housing by drug treatment interaction was not apparent in the open field.

KW - Housing environment

KW - MSG toxicity

KW - Neonatal administration

KW - Place navigation task

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Enriched housing masks deficits in place navigation induced by neonatal monosodium glutamate

Abstract

Keywords

ASJC Scopus subject areas

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