Enriched housing masks deficits in place navigation induced by neonatal monosodium glutamate

Matti J. Saari*, Shirley Fong, Amin Shivji, John N. Armstrong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Monosodium-L-glutamate (MSG)-induced behavioural deficits were examined under two housing conditions. Male Wistar rat pups were cross-fostered at birth and injected with MSG on days 2 to 11 postpartum. Control pups were injected with saline (Sal) of equivalent volume. Following weaning at day 25 the rats were allocated to either "enriched" (EC) or "impoverished" (IC) housing, thus forming four treatment groups: MSG-EC, MSG-IC, Sal-EC, and Sal-IC. Thirty-five days later all rats were tested in the open field and in the place navigation task. Multivariate analysis of variance (MANOVA) revealed a significant two-way interaction of the housing × drug variables. While the MSG-IC rats were deficient in the water maze, the performance of the MSG-EC approached that of saline-injected controls. Although the Sal-IC rats developed higher body weights than the Sal-EC rats the MSG-EC and MSG-IC rats did not differ in body weight. The housing by drug treatment interaction was not apparent in the open field.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalNeurotoxicology and Teratology
Issue number1
StatePublished - 1990
Externally publishedYes


  • Housing environment
  • MSG toxicity
  • Neonatal administration
  • Place navigation task

ASJC Scopus subject areas

  • Toxicology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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