Enrolling minors in COVID-19 vaccine trials

Kevin Mintz, E. Jardas, Seema Shah, Christine Grady, Marion Danis, David Wendler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


It is widely agreed that an effective response to the coronavirus disease 2019 pandemic needs to include a vaccine that is safe and effective for minors. However, many current vaccine trials have no plans for when to enroll minors. Others have recently proposed enrolling minors as young as 12 years old. This lack of a systematic approach raises 2 concerns. Waiting too long to enroll minors could unjustly deny minors and their families the benefits of a vaccine and has the potential to delay an effective response to the pandemic by a year or longer. At the same time, enrolling minors too soon runs the risk of exposing them to excessive risks. With these concerns in mind, in the present article, we propose recommendations for when and how to enroll minors in vaccine trials for the coronavirus disease 2019.

Original languageEnglish (US)
Article numbere2020040717
Issue number3
StatePublished - Mar 1 2021

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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