Entropic compression of interacting DNA loops

Sumithra Sankararaman*, John F. Marko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We solve a model for the equilibrium folding of DNA via the formation of randomly placed (nonspecific) loops. We find that the loop rearrangement entropy drives a significant reduction in loop size as more loops form. The reduction of the most probable loop size occurs over a wide range of forces and is enhanced by interloop cooperativity, indicating that it should be observable in single DNA experiments.

Original languageEnglish (US)
Article number078104
JournalPhysical review letters
Issue number7
StatePublished - Aug 12 2005

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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