Environmental factors associated with disease flare in juvenile and adult dermatomyositis

Gulnara Mamyrova*, Lisa G. Rider, Alison Ehrlich, Olcay Jones, Lauren M Pachman, Robert Nickeson, Lisa G. Criscone-Schreiber, Lawrence K. Jung, Frederick W. Miller, James D. Katz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Objective. The aim was to assess environmental factors associated with disease flare in juvenile and adult dermatomyositis (DM).Methods. An online survey of DM patients from the USA and Canada examined smoking, sun exposure, infections, medications, vaccines, stressful life events and physical activity during the 6 months before flares, or in the past 6 months in patients without flares. Differences were evaluated by χ2 and Fisher's exact tests, and significant univariable results were examined in multivariable logistic regression. Residential locations before flare were correlated with the National Weather Service UV index. Results. Of 210 participants (164 juvenile and 46 adult DM), 134 (63.8%) experienced a disease flare within 2 years of the survey. Subjects more often reported disease flare after sun exposure [odds ratio (OR) = 2.0, P = 0.03], although use of photoprotective measures did not differ between those with and without flare. Urinary tract infections (OR = 16.4, P = 0.005) and gastroenteritis (OR = 3.2, P = 0.04) were more frequent in the preceding 6 months in those who flared. Subjects who flared recently used NSAIDS (OR = 3.0, P = 0.0003), blood pressure medicines (OR = 3.5, P = 0.049) or medication for depression or mood changes (OR = 12.9, P = 0.015). Moving to a new house (OR = 10.3, P = 0.053) was more common in those who flared. Only sun exposure (OR = 2.2) and NSAIDs (OR = 1.9) were significant factors in multivariable analysis. Conclusion. Certain classes of environmental agents that have been associated with the initiation of DM, including sun exposure and medications, may also play a role in disease flares.

Original languageEnglish (US)
Pages (from-to)1342-1347
Number of pages6
JournalRheumatology (United Kingdom)
Volume56
Issue number8
DOIs
StatePublished - Aug 1 2017

Keywords

  • Dermatomyositis
  • Disease flare
  • Environmental factors
  • Juvenile dermatomyositis

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Environmental factors associated with disease flare in juvenile and adult dermatomyositis'. Together they form a unique fingerprint.

Cite this