Environmental toxicology of testicular cancer

Joshua J. Meeks, Joel Sheinfeld, Scott E. Eggener*

*Corresponding author for this work

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Objective: Testicular cancer incidence appears to be increasing. In many regions, industrialization results in the production of potentially carcinogenic environmental toxins. We review the available data linking environmental toxins to testicular germ cell tumors (TGCT). Methods: A PubMed review of the English literature was performed to identify studies evaluating the relationship between environmental toxins and TGCT. Results: Many environmental toxins have been implicated in the development of TGCT, including organochlorines, polychlorinated biphenyls, polyvinyl chlorides, phthalates, marijuana, and tobacco. Variable levels of evidence exist and significant study design limitations preclude a definitive etiologic role for individual environmental toxins. Conclusion: Environmental toxins may play an important but undetermined role in the development of TGCT. Further work is needed to evaluate specific toxins and TGCT carcinogenesis.

Original languageEnglish (US)
Pages (from-to)212-215
Number of pages4
JournalUrologic Oncology: Seminars and Original Investigations
Volume30
Issue number2
DOIs
StatePublished - Mar 1 2012

Fingerprint

Ecotoxicology
Testicular Neoplasms
Polychlorinated Biphenyls
Cannabis
Polyvinyl Chloride
PubMed
Tobacco
Carcinogenesis
Testicular Germ Cell Tumor
Incidence

Keywords

  • Environmental exposure
  • Germ cell tumor
  • Testicular neoplasm

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Meeks, Joshua J. ; Sheinfeld, Joel ; Eggener, Scott E. / Environmental toxicology of testicular cancer. In: Urologic Oncology: Seminars and Original Investigations. 2012 ; Vol. 30, No. 2. pp. 212-215.
@article{a3cec84451754de7a9e89b181ecfd40c,
title = "Environmental toxicology of testicular cancer",
abstract = "Objective: Testicular cancer incidence appears to be increasing. In many regions, industrialization results in the production of potentially carcinogenic environmental toxins. We review the available data linking environmental toxins to testicular germ cell tumors (TGCT). Methods: A PubMed review of the English literature was performed to identify studies evaluating the relationship between environmental toxins and TGCT. Results: Many environmental toxins have been implicated in the development of TGCT, including organochlorines, polychlorinated biphenyls, polyvinyl chlorides, phthalates, marijuana, and tobacco. Variable levels of evidence exist and significant study design limitations preclude a definitive etiologic role for individual environmental toxins. Conclusion: Environmental toxins may play an important but undetermined role in the development of TGCT. Further work is needed to evaluate specific toxins and TGCT carcinogenesis.",
keywords = "Environmental exposure, Germ cell tumor, Testicular neoplasm",
author = "Meeks, {Joshua J.} and Joel Sheinfeld and Eggener, {Scott E.}",
year = "2012",
month = "3",
day = "1",
doi = "10.1016/j.urolonc.2011.09.009",
language = "English (US)",
volume = "30",
pages = "212--215",
journal = "Urologic Oncology",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "2",

}

Environmental toxicology of testicular cancer. / Meeks, Joshua J.; Sheinfeld, Joel; Eggener, Scott E.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 30, No. 2, 01.03.2012, p. 212-215.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Environmental toxicology of testicular cancer

AU - Meeks, Joshua J.

AU - Sheinfeld, Joel

AU - Eggener, Scott E.

PY - 2012/3/1

Y1 - 2012/3/1

N2 - Objective: Testicular cancer incidence appears to be increasing. In many regions, industrialization results in the production of potentially carcinogenic environmental toxins. We review the available data linking environmental toxins to testicular germ cell tumors (TGCT). Methods: A PubMed review of the English literature was performed to identify studies evaluating the relationship between environmental toxins and TGCT. Results: Many environmental toxins have been implicated in the development of TGCT, including organochlorines, polychlorinated biphenyls, polyvinyl chlorides, phthalates, marijuana, and tobacco. Variable levels of evidence exist and significant study design limitations preclude a definitive etiologic role for individual environmental toxins. Conclusion: Environmental toxins may play an important but undetermined role in the development of TGCT. Further work is needed to evaluate specific toxins and TGCT carcinogenesis.

AB - Objective: Testicular cancer incidence appears to be increasing. In many regions, industrialization results in the production of potentially carcinogenic environmental toxins. We review the available data linking environmental toxins to testicular germ cell tumors (TGCT). Methods: A PubMed review of the English literature was performed to identify studies evaluating the relationship between environmental toxins and TGCT. Results: Many environmental toxins have been implicated in the development of TGCT, including organochlorines, polychlorinated biphenyls, polyvinyl chlorides, phthalates, marijuana, and tobacco. Variable levels of evidence exist and significant study design limitations preclude a definitive etiologic role for individual environmental toxins. Conclusion: Environmental toxins may play an important but undetermined role in the development of TGCT. Further work is needed to evaluate specific toxins and TGCT carcinogenesis.

KW - Environmental exposure

KW - Germ cell tumor

KW - Testicular neoplasm

UR - http://www.scopus.com/inward/record.url?scp=84857623416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857623416&partnerID=8YFLogxK

U2 - 10.1016/j.urolonc.2011.09.009

DO - 10.1016/j.urolonc.2011.09.009

M3 - Review article

C2 - 22385991

AN - SCOPUS:84857623416

VL - 30

SP - 212

EP - 215

JO - Urologic Oncology

JF - Urologic Oncology

SN - 1078-1439

IS - 2

ER -