Enzyme-directed assembly of a nanoparticle probe in tumor tissue

Miao Ping Chien; Matthew P. Thompson; Christopher V. Barback; Ti Hsuan Ku; David J. Hall; Nathan C. Gianneschi

doi:10.1002/adma.201300823

Enzyme-directed assembly of a nanoparticle probe in tumor tissue

Miao Ping Chien, Matthew P. Thompson, Christopher V. Barback, Ti Hsuan Ku, David J. Hall, Nathan C. Gianneschi^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time.

Original language	English (US)
Pages (from-to)	3599-3604
Number of pages	6
Journal	Advanced Materials
Volume	25
Issue number	26
DOIs	https://doi.org/10.1002/adma.201300823
State	Published - Jul 12 2013

Keywords

enzyme-responsive
in vivo probe
micelle
nanoparticles
peptide

ASJC Scopus subject areas

Mechanics of Materials
Mechanical Engineering
General Materials Science

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10.1002/adma.201300823

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AU - Chien, Miao Ping

AU - Thompson, Matthew P.

AU - Barback, Christopher V.

AU - Ku, Ti Hsuan

AU - Hall, David J.

AU - Gianneschi, Nathan C.

PY - 2013/7/12

Y1 - 2013/7/12

N2 - Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time.

AB - Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time.

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KW - in vivo probe

KW - micelle

KW - nanoparticles

KW - peptide

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Enzyme-directed assembly of a nanoparticle probe in tumor tissue

Abstract

Keywords

ASJC Scopus subject areas

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