Enzyme-directed assembly of a nanoparticle probe in tumor tissue

Miao Ping Chien, Matthew P. Thompson, Christopher V. Barback, Ti Hsuan Ku, David J. Hall, Nathan C. Gianneschi*

*Corresponding author for this work

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time.

Original languageEnglish (US)
Pages (from-to)3599-3604
Number of pages6
JournalAdvanced Materials
Volume25
Issue number26
DOIs
StatePublished - Jul 12 2013

Keywords

  • enzyme-responsive
  • in vivo probe
  • micelle
  • nanoparticles
  • peptide

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Chien, M. P., Thompson, M. P., Barback, C. V., Ku, T. H., Hall, D. J., & Gianneschi, N. C. (2013). Enzyme-directed assembly of a nanoparticle probe in tumor tissue. Advanced Materials, 25(26), 3599-3604. https://doi.org/10.1002/adma.201300823