Enzyme Inhibition

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary

Abstract

This article describes various approaches to inhibition of enzyme catalysis. Reversible inhibition includes competitive, uncompetitive, mixed inhibition, noncompetitive inhibition, transition state, and slow tight-binding inhibition. Irreversible inhibition approaches include affinity labeling and mechanism-based enzyme inhibition. The kinetics of the various inhibition approaches are summarized, and examples of each type of inhibition are presented.
Original languageEnglish (US)
Title of host publicationWiley Encyclopedia of Chemical Biology
EditorsTadhg P Begley
Pages663-681
Number of pages19
Volume1
StatePublished - 2008

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