| Original language | English (US) |
|---|---|
| Title of host publication | Wiley Encyclopedia of Chemical Biology |
| Editors | Tadhg P Begley |
| Pages | 663-681 |
| Number of pages | 19 |
| Volume | 1 |
| State | Published - 2008 |
Abstract
This article describes various approaches to inhibition of enzyme catalysis. Reversible inhibition includes competitive, uncompetitive, mixed inhibition, noncompetitive inhibition, transition state, and slow tight-binding inhibition. Irreversible inhibition approaches include affinity labeling and mechanism-based enzyme inhibition. The kinetics of the various inhibition approaches are summarized, and examples of each type of inhibition are presented.