|Original language||English (US)|
|Title of host publication||Wiley Encyclopedia of Chemical Biology|
|Editors||Tadhg P Begley|
|Number of pages||19|
|State||Published - 2008|
This article describes various approaches to inhibition of enzyme catalysis. Reversible inhibition includes competitive, uncompetitive, mixed inhibition, noncompetitive inhibition, transition state, and slow tight-binding inhibition. Irreversible inhibition approaches include affinity labeling and mechanism-based enzyme inhibition. The kinetics of the various inhibition approaches are summarized, and examples of each type of inhibition are presented.