Abstract
A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.
Original language | English (US) |
---|---|
Pages (from-to) | 5547-5552 |
Number of pages | 6 |
Journal | Advanced Materials |
Volume | 27 |
Issue number | 37 |
DOIs | |
State | Published - Oct 1 2015 |
Keywords
- MMPs
- enzyme-responsive
- intravenous injection
- myocardial infarction
- nanoparticles
ASJC Scopus subject areas
- General Materials Science
- Mechanics of Materials
- Mechanical Engineering