Enzyme-responsive nanoparticles for the treatment of disease

Cassandra E. Callmann, Nathan C. Gianneschi*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nanomedicine for cancer therapy seeks to treat malignancies through the selective accumulation of therapeutics in diseased tissue. Nanoparticles offer the convenience of high drug loading capacities and can be readily decorated with targeting moieties, drugs, and/or diagnostics. Our lab has pioneered a new tissue targeting strategy where enhanced accumulation of nanomaterials occurs as a result of morphology changes to the material in response to overexpressed enzymes in diseased tissues. Herein, we describe the general strategy for the preparation of these enzyme-responsive nanoparticles (ER-NPs) for therapeutic applications.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages223-238
Number of pages16
Volume1570
DOIs
StatePublished - Jan 1 2017

Publication series

NameMethods in Molecular Biology
Volume1570
ISSN (Print)1064-3745

Keywords

  • Enzyme-responsive nanoparticles
  • Nanomedicine
  • Nanoparticles
  • Self-assembly

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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