Abstract
Open-to-air aqueous-phase ring-opening metathesis polymerization-induced self-assembly (ROMPISA) is reported for forming well-defined peptide polymer nanoparticles at room temperature and with high solids concentrations (10 w/w%). For these materials, ROMPISA is shown to provide control over molecular weight with high conversion while open-to-air. Moreover, these peptide polymer nanoparticles can spontaneously rearrange into larger aggregate scaffolds in the presence of the proteolytic enzyme, thermolysin. This work demonstrates the robust nature of ROMPISA, highlighted here for the preparation of stimuli-responsive nanostructures in one pot, in air.
| Original language | English (US) |
|---|---|
| Article number | 1800467 |
| Journal | Macromolecular Rapid Communications |
| Volume | 40 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 2019 |
Funding
This research was conducted with government support under and awarded by DoD through a MURI from the Air Force Office of Scientific Research (FA-9550-16-1-0150) and a National Defense Science and Engineering Graduate (NDSEG) Fellowship, 32 CFR 168a. This work made use of the BioCryo facility of Northwestern University’s NUANCE Center, which has received support from the Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205); the MRSEC program (NSF DMR-1720139) at the Materials Research Center; the International Institute for Nanotechnology (IIN); and the State of Illinois, through the IIN. Apeiron is thanked for the aqueous initiator (Aquamet).
Keywords
- ROMPISA
- block copolymers
- peptides
- self-assembly
ASJC Scopus subject areas
- Polymers and Plastics
- Organic Chemistry
- Materials Chemistry