Eosinophilia correlates with the presence or development of chronic graft-versus-host disease in children

David A. Jacobsohn; Tali Schechter; Roopa Seshadri; Kimberly Thormann; Reggie Duerst; Morris Kletzel

doi:10.1097/01.TP.0000118409.92769.FA

Eosinophilia correlates with the presence or development of chronic graft-versus-host disease in children

David A. Jacobsohn^*, Tali Schechter, Roopa Seshadri, Kimberly Thormann, Reggie Duerst, Morris Kletzel

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Finding predictors of chronic graft-versus-host disease (cGVIID) in children would be extremely useful. Because of recent data suggesting that cGVHD may be a Th-2-mediated process, a theoretical foundation linking eosinophilia and cGVHD exists. While an association between eosinophilia and cGVHD has been described in adults, it has never been described in children. We studied 53 patients that received allogeneic hematopoietic stem cell transplants (SCT) between 1999 and 2002. Ten (19%) of these patients developed eosinophilia (absolute eosinophil count (AEC) > 500× 10⁶/L) after day 100. Of these ten, eight either had or later developed cGVHD. We conclude that following the peripheral eosinophil count in children post-SCT is useful, and a rise in the AEC may herald the development of cGVHD. Taking the AEC into account with other risk factors (such as previous grade II-IV acute GVHD, human leukocyte antigen (HLA)-mismatch, and unrelated donor (URD) transplant) may improve our ability to predict cGVHD.

Original language	English (US)
Pages (from-to)	1096-1100
Number of pages	5
Journal	Transplantation
Volume	77
Issue number	7
DOIs	https://doi.org/10.1097/01.TP.0000118409.92769.FA
State	Published - Apr 15 2004

ASJC Scopus subject areas

Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/01.TP.0000118409.92769.FA

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abstract = "Finding predictors of chronic graft-versus-host disease (cGVIID) in children would be extremely useful. Because of recent data suggesting that cGVHD may be a Th-2-mediated process, a theoretical foundation linking eosinophilia and cGVHD exists. While an association between eosinophilia and cGVHD has been described in adults, it has never been described in children. We studied 53 patients that received allogeneic hematopoietic stem cell transplants (SCT) between 1999 and 2002. Ten (19%) of these patients developed eosinophilia (absolute eosinophil count (AEC) > 500× 106/L) after day 100. Of these ten, eight either had or later developed cGVHD. We conclude that following the peripheral eosinophil count in children post-SCT is useful, and a rise in the AEC may herald the development of cGVHD. Taking the AEC into account with other risk factors (such as previous grade II-IV acute GVHD, human leukocyte antigen (HLA)-mismatch, and unrelated donor (URD) transplant) may improve our ability to predict cGVHD.",

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AU - Jacobsohn, David A.

AU - Schechter, Tali

AU - Seshadri, Roopa

AU - Thormann, Kimberly

AU - Duerst, Reggie

AU - Kletzel, Morris

PY - 2004/4/15

Y1 - 2004/4/15

N2 - Finding predictors of chronic graft-versus-host disease (cGVIID) in children would be extremely useful. Because of recent data suggesting that cGVHD may be a Th-2-mediated process, a theoretical foundation linking eosinophilia and cGVHD exists. While an association between eosinophilia and cGVHD has been described in adults, it has never been described in children. We studied 53 patients that received allogeneic hematopoietic stem cell transplants (SCT) between 1999 and 2002. Ten (19%) of these patients developed eosinophilia (absolute eosinophil count (AEC) > 500× 106/L) after day 100. Of these ten, eight either had or later developed cGVHD. We conclude that following the peripheral eosinophil count in children post-SCT is useful, and a rise in the AEC may herald the development of cGVHD. Taking the AEC into account with other risk factors (such as previous grade II-IV acute GVHD, human leukocyte antigen (HLA)-mismatch, and unrelated donor (URD) transplant) may improve our ability to predict cGVHD.

AB - Finding predictors of chronic graft-versus-host disease (cGVIID) in children would be extremely useful. Because of recent data suggesting that cGVHD may be a Th-2-mediated process, a theoretical foundation linking eosinophilia and cGVHD exists. While an association between eosinophilia and cGVHD has been described in adults, it has never been described in children. We studied 53 patients that received allogeneic hematopoietic stem cell transplants (SCT) between 1999 and 2002. Ten (19%) of these patients developed eosinophilia (absolute eosinophil count (AEC) > 500× 106/L) after day 100. Of these ten, eight either had or later developed cGVHD. We conclude that following the peripheral eosinophil count in children post-SCT is useful, and a rise in the AEC may herald the development of cGVHD. Taking the AEC into account with other risk factors (such as previous grade II-IV acute GVHD, human leukocyte antigen (HLA)-mismatch, and unrelated donor (URD) transplant) may improve our ability to predict cGVHD.

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Eosinophilia correlates with the presence or development of chronic graft-versus-host disease in children

Abstract

ASJC Scopus subject areas

UN SDGs

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