Eosinophilic esophagitis: Overview of clinical management

Alain M. Schoepfer, Ikuo Hirano*, David A. Katzka

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

A validated disease-specific symptom-assessment tool for eosinophilic esophagitis (EoE) has yet to be approved by regulatory authorities for use in clinical trials. Relevant end points for daily practice include EoE-related symptoms and esophageal eosinophilic inflammation. Endoscopic features should also be taken into account when establishing a therapy plan. A reasonable clinical goal is to achieve a reduction in EoE-related symptoms and esophageal eosinophilic inflammation. Evidence is increasing to support an anti-inflammatory maintenance therapy, as this can reduce esophageal remodeling. In EoE patients in clinical remission, annual disease monitoring with symptom, endoscopic, and histologic assessments of sustained treatment response is recommended.

Original languageEnglish (US)
Pages (from-to)329-344
Number of pages16
JournalGastroenterology Clinics of North America
Volume43
Issue number2
DOIs
StatePublished - Jun 2014

Keywords

  • Dysphagia
  • Eosinophilic esophagitis
  • Gastroesophageal reflux disease
  • Patient-reported outcomes
  • Treatment end points

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Eosinophilic esophagitis: Overview of clinical management'. Together they form a unique fingerprint.

Cite this