Eosinophilic gastrointestinal diseases-clinically diverse and histopathologically confounding

Seema Aceves, Ikuo Hirano, Glenn T. Furuta*, Margaret H. Collins

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Eosinophilic gastrointestinal diseases are a group of chronic diseases characterized by a range of symptoms caused by eosinophilic inflammation of various parts of the gastrointestinal tract. Other causes for eosinophilia need to be ruled out prior to making the diagnosis of EGIDs. The most common form of EGID is eosinophilic esophagitis (EoE), an antigen-driven disease that afflicts children and adults and has been identified across the world. Histological features include dense eosinophilia of the esophageal mucosa, eosinophil degranulation, eosinophil microabscess formation, and other features of epithelial inflammation including basal zone hyperplasia and rete pege elongation. Treatments include dietary exclusions and topical corticosteroids.

Original languageEnglish (US)
Pages (from-to)715-731
Number of pages17
JournalSeminars in Immunopathology
Volume34
Issue number5
DOIs
StatePublished - Sep 1 2012

Keywords

  • Eosinophilic esophagitis
  • Esophagitis
  • Gastrointestinal allergy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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