Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse

Elizabeth J. Quackenbush*, Vincent Aguirre, Barry K. Wershil, Jose Carlos Gutierrez-Ramos

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Eotaxin is a potent chemoattractant for eosinophils during inflammation and allergic reactions in the adult, but its role during development has not been studied. We report that eotaxin and its receptor, CCR-3, are expressed by embryonic tissues responsible for blood development, including the yolk sac, fetal liver, and fetal blood. We also found that eotaxin acts synergistically with stem cell factor (SCF) to accelerate the differentiation of embryonic mast cell progenitors and to promote the growth of Mac-1+/Gr- 1- cells from progenitors isolated at 10-12 days of gestation. This response is diminished by Pertussis toxin, the G(iα) inhibitor. These studies suggest that eotaxin is involved in the growth of myeloid cell progenitors and the differentiation of mast cells during embryogenic development.

Original languageEnglish (US)
Pages (from-to)661-666
Number of pages6
JournalJournal of Leukocyte Biology
Volume62
Issue number5
DOIs
StatePublished - Nov 1997

Keywords

  • CCR-3
  • Embryogenesis
  • Hematopoiesis
  • Mast cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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