Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse

Elizabeth J. Quackenbush; Vincent Aguirre; Barry K. Wershil; Jose Carlos Gutierrez-Ramos

doi:10.1002/jlb.62.5.661

Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse

Elizabeth J. Quackenbush^*, Vincent Aguirre, Barry K. Wershil, Jose Carlos Gutierrez-Ramos

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Eotaxin is a potent chemoattractant for eosinophils during inflammation and allergic reactions in the adult, but its role during development has not been studied. We report that eotaxin and its receptor, CCR-3, are expressed by embryonic tissues responsible for blood development, including the yolk sac, fetal liver, and fetal blood. We also found that eotaxin acts synergistically with stem cell factor (SCF) to accelerate the differentiation of embryonic mast cell progenitors and to promote the growth of Mac-1⁺/Gr- 1^- cells from progenitors isolated at 10-12 days of gestation. This response is diminished by Pertussis toxin, the G(iα) inhibitor. These studies suggest that eotaxin is involved in the growth of myeloid cell progenitors and the differentiation of mast cells during embryogenic development.

Original language	English (US)
Pages (from-to)	661-666
Number of pages	6
Journal	Journal of Leukocyte Biology
Volume	62
Issue number	5
DOIs	https://doi.org/10.1002/jlb.62.5.661
State	Published - Nov 1997

Keywords

CCR-3
Embryogenesis
Hematopoiesis
Mast cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Cell Biology

Access to Document

10.1002/jlb.62.5.661

Cite this

@article{b1b2186ad2904665a4038aec30d6ebdd,

title = "Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse",

abstract = "Eotaxin is a potent chemoattractant for eosinophils during inflammation and allergic reactions in the adult, but its role during development has not been studied. We report that eotaxin and its receptor, CCR-3, are expressed by embryonic tissues responsible for blood development, including the yolk sac, fetal liver, and fetal blood. We also found that eotaxin acts synergistically with stem cell factor (SCF) to accelerate the differentiation of embryonic mast cell progenitors and to promote the growth of Mac-1+/Gr- 1- cells from progenitors isolated at 10-12 days of gestation. This response is diminished by Pertussis toxin, the G(iα) inhibitor. These studies suggest that eotaxin is involved in the growth of myeloid cell progenitors and the differentiation of mast cells during embryogenic development.",

keywords = "CCR-3, Embryogenesis, Hematopoiesis, Mast cells",

author = "Quackenbush, {Elizabeth J.} and Vincent Aguirre and Wershil, {Barry K.} and Gutierrez-Ramos, {Jose Carlos}",

year = "1997",

month = nov,

doi = "10.1002/jlb.62.5.661",

language = "English (US)",

volume = "62",

pages = "661--666",

journal = "Journal of Leukocyte Biology",

issn = "0741-5400",

publisher = "FASEB",

number = "5",

}

TY - JOUR

T1 - Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse

AU - Quackenbush, Elizabeth J.

AU - Aguirre, Vincent

AU - Wershil, Barry K.

AU - Gutierrez-Ramos, Jose Carlos

PY - 1997/11

Y1 - 1997/11

N2 - Eotaxin is a potent chemoattractant for eosinophils during inflammation and allergic reactions in the adult, but its role during development has not been studied. We report that eotaxin and its receptor, CCR-3, are expressed by embryonic tissues responsible for blood development, including the yolk sac, fetal liver, and fetal blood. We also found that eotaxin acts synergistically with stem cell factor (SCF) to accelerate the differentiation of embryonic mast cell progenitors and to promote the growth of Mac-1+/Gr- 1- cells from progenitors isolated at 10-12 days of gestation. This response is diminished by Pertussis toxin, the G(iα) inhibitor. These studies suggest that eotaxin is involved in the growth of myeloid cell progenitors and the differentiation of mast cells during embryogenic development.

AB - Eotaxin is a potent chemoattractant for eosinophils during inflammation and allergic reactions in the adult, but its role during development has not been studied. We report that eotaxin and its receptor, CCR-3, are expressed by embryonic tissues responsible for blood development, including the yolk sac, fetal liver, and fetal blood. We also found that eotaxin acts synergistically with stem cell factor (SCF) to accelerate the differentiation of embryonic mast cell progenitors and to promote the growth of Mac-1+/Gr- 1- cells from progenitors isolated at 10-12 days of gestation. This response is diminished by Pertussis toxin, the G(iα) inhibitor. These studies suggest that eotaxin is involved in the growth of myeloid cell progenitors and the differentiation of mast cells during embryogenic development.

KW - CCR-3

KW - Embryogenesis

KW - Hematopoiesis

KW - Mast cells

UR - http://www.scopus.com/inward/record.url?scp=0030664301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030664301&partnerID=8YFLogxK

U2 - 10.1002/jlb.62.5.661

DO - 10.1002/jlb.62.5.661

M3 - Article

C2 - 9365121

AN - SCOPUS:0030664301

SN - 0741-5400

VL - 62

SP - 661

EP - 666

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

IS - 5

ER -

Eotaxin influences the development of embryonic hematopoietic progenitors in the mouse

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this