Epedimic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome

Alan M. Krensky; Stafford Grady; Karen M. Shanley; William Berenberg; Edmond J. Yunis

doi:10.1016/0198-8859(83)90063-0

Epedimic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome

Alan M. Krensky^*, Stafford Grady, Karen M. Shanley, William Berenberg, Edmond J. Yunis

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Abstract

HLA-A,B and DR antigens were evaluated in 51 patients with mucocutaneous lymph node syndrome (Kawasaki disease) during both endemic and epidemic periods in the Boston area. Although 80% of patients were HLA-B5 (70% HLA-Bw51) during endemic periods, there were no HLA-B5 individuals during the epidemic period. There was, however, an increased incidence of HLA-Bw44 during the Boston epidemic. Such different associations in endemic versus epidemic periods suggest possible different, as yet unknown, inciting agents.

Original language	English (US)
Pages (from-to)	75-77
Number of pages	3
Journal	Human Immunology
Volume	6
Issue number	2
DOIs	https://doi.org/10.1016/0198-8859(83)90063-0
State	Published - 1983

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Epedimic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome",

abstract = "HLA-A,B and DR antigens were evaluated in 51 patients with mucocutaneous lymph node syndrome (Kawasaki disease) during both endemic and epidemic periods in the Boston area. Although 80% of patients were HLA-B5 (70% HLA-Bw51) during endemic periods, there were no HLA-B5 individuals during the epidemic period. There was, however, an increased incidence of HLA-Bw44 during the Boston epidemic. Such different associations in endemic versus epidemic periods suggest possible different, as yet unknown, inciting agents.",

author = "Krensky, {Alan M.} and Stafford Grady and Shanley, {Karen M.} and William Berenberg and Yunis, {Edmond J.}",

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doi = "10.1016/0198-8859(83)90063-0",

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T1 - Epedimic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome

AU - Krensky, Alan M.

AU - Grady, Stafford

AU - Shanley, Karen M.

AU - Berenberg, William

AU - Yunis, Edmond J.

PY - 1983

Y1 - 1983

N2 - HLA-A,B and DR antigens were evaluated in 51 patients with mucocutaneous lymph node syndrome (Kawasaki disease) during both endemic and epidemic periods in the Boston area. Although 80% of patients were HLA-B5 (70% HLA-Bw51) during endemic periods, there were no HLA-B5 individuals during the epidemic period. There was, however, an increased incidence of HLA-Bw44 during the Boston epidemic. Such different associations in endemic versus epidemic periods suggest possible different, as yet unknown, inciting agents.

AB - HLA-A,B and DR antigens were evaluated in 51 patients with mucocutaneous lymph node syndrome (Kawasaki disease) during both endemic and epidemic periods in the Boston area. Although 80% of patients were HLA-B5 (70% HLA-Bw51) during endemic periods, there were no HLA-B5 individuals during the epidemic period. There was, however, an increased incidence of HLA-Bw44 during the Boston epidemic. Such different associations in endemic versus epidemic periods suggest possible different, as yet unknown, inciting agents.

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Epedimic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome

Abstract

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