Ependymomas in children: Histologic and DNA-flow cytometric study

Miguel Reyes-Mugica*, Pauline M Chou, Moe Moe Myint, Cecilia Ridaura-Sanz, Frank Gonzalez-Crussi, Tadanori Tomita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Ependymoma, a common neoplasm in the central nervous system of children, expresses great variability of morphological appearances. Correlation with clinical behavior has been controversial in previous studies. In order to explore the potential value of DNA-flow cytometric analysis in predicting the clinical course of ependymomas in children, we studied 22 patients with this tumor, selected from two large pediatric institutions. In addition, a number of histologic features were reviewed, such as necrosis, mitoses, endothelial proliferation, cellularity, and pleomorphism. DNA analyses of paraffin-embedded tissue from these tumors showed 9 of 17 (53% with DNA indexes less than 1.16 and 8 of 17 (47% with DNA indexes above 1.16. Ten of 17 (59% patients died, 2 (12% were lost for follow-up, and 5 (29% are alive. No statistical correlation was found between DNA index, outcome, and histology. In spite of the small sample size, our findings appear to support the general impression that ependymomas are morphologically highly variable tumors of potential aggressiveness without valuable prognostic histologic markers..

Original languageEnglish (US)
Pages (from-to)453-466
Number of pages14
JournalFetal and Pediatric Pathology
Volume14
Issue number3
DOIs
StatePublished - Jan 1 1994

Keywords

  • DNA-flow cytometry
  • Ependymoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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