Eph receptor and ephrin function in breast, gut, and skin epithelia

Bethany E.Perez White, Spiro Getsios*

*Corresponding author for this work

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Epithelial cells are tightly coupled together through specialized intercellular junctions, including adherens junctions, desmosomes, tight junctions, and gap junctions. A growing body of evidence suggests epithelial cells also directly exchange information at cell-cell contacts via the Eph family of receptor tyrosine kinases and their membrane-associated ephrin ligands. Ligand-dependent and -independent signaling via Eph receptors as well as reverse signaling through ephrins impact epithelial tissue homeostasis by organizing stem cell compartments and regulating cell proliferation, migration, adhesion, differentiation, and survival. This review focuses on breast, gut, and skin epithelia as representative examples for how Eph receptors and ephrins modulate diverse epithelial cell responses in a context-dependent manner. Abnormal Eph receptor and ephrin signaling is implicated in a variety of epithelial diseases raising the intriguing possibility that this cellcell communication pathway can be therapeutically harnessed to normalize epithelial function in pathological settings like cancer or chronic inflammation.

Original languageEnglish (US)
Pages (from-to)327-338
Number of pages12
JournalCell Adhesion and Migration
Volume8
Issue number4
DOIs
StatePublished - Jul 1 2014

Keywords

  • Breast
  • Cell-cell
  • Eph receptor
  • Ephrin
  • Epithelial
  • Intestine
  • Receptor tyrosine kinase
  • Skin
  • Stem cell

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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