Ephrin-As guide the formation of functional maps in the visual cortex

Jianhua Cang, Megumi Kaneko, Jena Yamada, Georgia Woods, Michael P. Stryker*, David A. Feldheim

*Corresponding author for this work

Research output: Contribution to journalArticle

132 Scopus citations


Ephrin-As and their receptors, EphAs, are expressed in the developing cortex where they may act to organize thalamic inputs. Here, we map the visual cortex (V1) in mice deficient for ephrin-A2, -A3, and -A5 functionally, using intrinsic signal optical imaging and microelectrode recording, and structurally, by anatomical tracing of thalamocortical projections. V1 is shifted medially, rotated, and compressed and its internal organization is degraded. Expressing ephrin-A5 ectopically by in utero electroporation in the lateral cortex shifts the map of V1 medially, and expression within V1 disrupts its internal organization. These findings indicate that interactions between gradients of EphA/ephrin-A in the cortex guide map formation, but that factors other than redundant ephrin-As are responsible for the remnant map. Together with earlier work on the retinogeniculate map, the current findings show that the same molecular interactions may operate at successive stages of the visual pathway to organize maps.

Original languageEnglish (US)
Pages (from-to)577-589
Number of pages13
Issue number4
StatePublished - Nov 23 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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    Cang, J., Kaneko, M., Yamada, J., Woods, G., Stryker, M. P., & Feldheim, D. A. (2005). Ephrin-As guide the formation of functional maps in the visual cortex. Neuron, 48(4), 577-589. https://doi.org/10.1016/j.neuron.2005.10.026