TY - JOUR
T1 - Epidemiology and Management of Emerging Drug-Resistant Gram-Negative Bacteria
T2 - Extended-Spectrum β-Lactamases and Beyond
AU - Boyle, Daniel P.
AU - Zembower, Teresa R.
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015/11
Y1 - 2015/11
N2 - Worldwide prevalence of antimicrobial resistance is rapidly increasing, primarily a result of antibiotic misuse in the medical community. Resistant infections involving the urinary tract are typically caused by gram-negative bacteria. When treating these infections, clinicians have few effective antimicrobials to choose from and many are associated with significant adverse effects. There are now situations when clinicians are tasked with managing infections from pan-resistant organisms; thus, it is of paramount importance that spread of resistance be controlled. This review discusses common gram-negative resistance classes, highlighting the mechanisms of resistance, risk factors, type of infections, treatment, and outcomes associated with each class.
AB - Worldwide prevalence of antimicrobial resistance is rapidly increasing, primarily a result of antibiotic misuse in the medical community. Resistant infections involving the urinary tract are typically caused by gram-negative bacteria. When treating these infections, clinicians have few effective antimicrobials to choose from and many are associated with significant adverse effects. There are now situations when clinicians are tasked with managing infections from pan-resistant organisms; thus, it is of paramount importance that spread of resistance be controlled. This review discusses common gram-negative resistance classes, highlighting the mechanisms of resistance, risk factors, type of infections, treatment, and outcomes associated with each class.
KW - Antibiotic resistance
KW - Carbapenem-resistant Acinetobacter baumannii
KW - Carbapenem-resistant enterobacteriaceae
KW - Extended-spectrum β-lactamases
KW - Multidrug-resistant Pseudomonas aeruginosa
KW - New Delhi metallo-β-lactamase
UR - http://www.scopus.com/inward/record.url?scp=84944679126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944679126&partnerID=8YFLogxK
U2 - 10.1016/j.ucl.2015.05.005
DO - 10.1016/j.ucl.2015.05.005
M3 - Review article
C2 - 26475946
AN - SCOPUS:84944679126
SN - 0094-0143
VL - 42
SP - 493
EP - 505
JO - Urologic Clinics of North America
JF - Urologic Clinics of North America
IS - 4
ER -