Epidemiology of acute kidney injury in children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference

the ADQI 26 workgroup

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The nephrology and critical care communities have seen an increase in studies exploring acute kidney injury (AKI) epidemiology in children. As a result, we now know that AKI is highly prevalent in critically ill neonates, children, and young adults. Furthermore, children who develop AKI experience greater morbidity and higher mortality. Yet knowledge gaps still exist that suggest a more comprehensive understanding of AKI will form the foundation for future efforts designed to improve outcomes. In particular, the areas of community acquired AKI, AKI in non-critically ill children, and cohorts from low-middle income countries have not been well studied. Longer-term functional outcomes and patient-centric metrics including social determinants of health, quality of life, and healthcare utilization should be the foci of the next phase of scholarship. Current definitions identify AKI-based upon evidence of dysfunction which serves as a proxy for injury; biomarkers capable of identifying injury as it occurs are likely to more accurately define populations with AKI. Despite the strength of the association, the causal and mechanistic relationships between AKI and poorer outcomes remain inadequately examined. A more robust understanding of the relationship represents a potential to identify therapeutic targets. Once established, a more comprehensive understanding of AKI epidemiology in children will allow investigation of preventive, therapeutic, and quality improvement interventions more effectively.

Original languageEnglish (US)
Pages (from-to)919-928
Number of pages10
JournalPediatric Nephrology
Volume39
Issue number3
DOIs
StatePublished - Mar 2024

Funding

The ADQI 26 workgroup: The following individuals contributed to the formulation and content of this work in accordance with their participation in the 26thAcute Disease Quality Initiative (ADQI XXVI). Chairs: Ayse Akcan Arikan, MD, Baylor College of Medicine, Department of Pediatrics, Divisions of Critical Care Medicine and Nephrology, Houston, TX, USA. Rajit K. Basu, MD, MS, Northwestern University Feinberg School of Medicine, Ann & Robert Lurie Children’s Hospital of Chicago, Department of Pediatrics, Division of Critical Care Medicine, Chicago, IL, USA. Stuart L. Goldstein, MD, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, Division of Nephrology & Hypertension, Cincinnati, OH, USA. Members: Rashid Alobaidi1, David J. Askenazi2, Sean M. Bagshaw1, Matthew Barhight3, Erin Barreto4, Benan Bayrakci5, O. N. Ray Bignall II6, Erica Bjornstad2, Patrick Brophy7, Jennifer Charlton8, Rahul Chanchlani9, Andrea L. Conroy10, Akash Deep11, Prasad Devarajan12, Kristin Dolan13, Dana Y. Fuhrman14, Katja M. Gist12, Stephen M. Gorga15, Jason H. Greenberg16, Denise Hasson12, Emma Heydari1, Arpana Iyengar17, Jennifer Jetton18, Catherine Krawczeski6, Leslie Meigs19, Shina Menon20, Catherine Morgan1, Jolyn Morgan12, Theresa Mottes3, Tara Neumayr21, Zaccaria Ricci22, David T. Selewski23, Danielle Soranno10, Natalja Stanski12, Michelle Starr10, Scott M. Sutherland24, Jordan Symons20, Marcelo Tavares25, Molly Vega26, Michael Zappitelli27, Claudio Ronco28, Ravindra L. Mehta29, John Kellum30, and Marlies Ostermann311Alberta Health Sciences University, Edmonton, Alberta, Canada2University of Alabama at Birmingham, Children’s Hospital of Alabama, Birmingham, AL, USA3Northwestern University Feinberg School of Medicine, Ann & Robert Lurie Children’s Hospital of Chicago, Chicago, IL, USA4Hacettepe University, Ankara, Türkiye5Mayo Clinic, Rochester, MN, USA6Nationwide Children’s Hospital, Ohio State University, Columbus, OH, USA7Golisano Children’s Hospital, Rochester University Medical Center, Rochester, NY, USA8University of Virginia, Charlottesville, VA, USA9McMaster University, McMaster Children’s Hospital, Hamilton, ON, Canada10Riley Children’s Hospital, Indiana University School of Medicine, Indianapolis, IN, USA11King’s College London, King’s College Hospital NHS Foundation Trust, London, UK12Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA13Mercy Children’s Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA14Children’s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA15C.S. Mott Children’s Hospital, University of Michigan, Ann Arbor, MI, USA16Yale University Medical Center, New Haven, CT, USA17St. John’s National Academy of Health Sciences, Bangalore, India18Stead Family Children’s Hospital, University of Iowa, Iowa City, IA, USA19University of St. Thomas, Houston, TX USA20Seattle Children’s Hospital, University of Washington, Seattle, WA, USA21Washington University School of Medicine, St. Louis, MO, USA22University of Florence, Florence, Italy23Medical University of South Carolina, Charleston, SC, USA24Lucille Packard Children’s Hospital, Stanford University, Palo Alto, CA, USA25Santa Casa dela Belo Horizonte, Belo Horizonte, Brazil26Texas Children’s Hospital, Baylor College of Medicine, Houston, TX, USA27Hospital for Sick Children, Toronto, Ontario, Canada28San Bartolo Hospital, Universiti di Padova, Vicenza, Italy29University of California San Diego School of Medicine, La Jolla, CA, USA30University of Pittsburgh Medical Center, Pittsburgh, PA, USA31Guy’s and St. Thomas’ NHS Foundation Trust, London, UK

Keywords

  • ADQI
  • AKI epidemiology
  • Acute kidney injury

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Fingerprint

Dive into the research topics of 'Epidemiology of acute kidney injury in children: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference'. Together they form a unique fingerprint.

Cite this