Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination

Gilbert T. Chua, Mike Yat Wah Kwan, Celine S.L. Chui, Robert David Smith, Edmund Chi Lok Cheung, Tian Ma, Miriam T.Y. Leung, Sabrina Siu Ling Tsao, Elaine Kan, Wing Kei Carol Ng, Victor Chi Man Chan, Shuk Mui Tai, Tak Ching Yu, Kwok Piu Lee, Joshua Sung Chih Wong, Ying Kit Lin, Chi Chiu Shek, Agnes Sze Yin Leung, Chit Kwong Chow, Ka Wah LiJohnny Ma, Wai Yuk Fung, Daniel Lee, Ming Yen Ng, Wilfred Hing Sang Wong, Hing Wai Tsang, Janette Kwok, Daniel Leung, Kin Lai Chung, Chun Bong Chow, Godfrey Chi Fung Chan, Wing Hang Leung, Kelvin Kai Wang To, Kwok Yung Yuen, Yu Lung Lau, Ian Chi Kei Wong, Patrick Ip

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

BACKGROUND: Age-specific incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis/pericarditis among Hong Kong adolescents following Comirnaty vaccination. METHODS: This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination were analyzed. RESULTS: Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis/pericarditis was 18.52 (95% confidence interval [CI], 11.67-29.01) per 100 000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12-9.51) and 21.22 (95% CI, 13.78-32.28 per 100 000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38-12.53) and 37.32 (95% CI, 26.98-51.25) per 100 000 persons vaccinated. CONCLUSIONS: There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose.

Original languageEnglish (US)
Pages (from-to)673-681
Number of pages9
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume75
Issue number4
DOIs
StatePublished - Sep 10 2022

Keywords

  • Comirnaty
  • Hong Kong
  • adolescents
  • myocarditis
  • pericarditis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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