Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination

Gilbert T. Chua; Mike Yat Wah Kwan; Celine S.L. Chui; Robert David Smith; Edmund Chi Lok Cheung; Tian Ma; Miriam T.Y. Leung; Sabrina Siu Ling Tsao; Elaine Kan; Wing Kei Carol Ng; Victor Chi Man Chan; Shuk Mui Tai; Tak Ching Yu; Kwok Piu Lee; Joshua Sung Chih Wong; Ying Kit Lin; Chi Chiu Shek; Agnes Sze Yin Leung; Chit Kwong Chow; Ka Wah Li; Johnny Ma; Wai Yuk Fung; Daniel Lee; Ming Yen Ng; Wilfred Hing Sang Wong; Hing Wai Tsang; Janette Kwok; Daniel Leung; Kin Lai Chung; Chun Bong Chow; Godfrey Chi Fung Chan; Wing Hang Leung; Kelvin Kai Wang To; Kwok Yung Yuen; Yu Lung Lau; Ian Chi Kei Wong; Patrick Ip

doi:10.1093/cid/ciab989

Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination

Gilbert T. Chua, Mike Yat Wah Kwan, Celine S.L. Chui, Robert David Smith, Edmund Chi Lok Cheung, Tian Ma, Miriam T.Y. Leung, Sabrina Siu Ling Tsao, Elaine Kan, Wing Kei Carol Ng, Victor Chi Man Chan, Shuk Mui Tai, Tak Ching Yu, Kwok Piu Lee, Joshua Sung Chih Wong, Ying Kit Lin, Chi Chiu Shek, Agnes Sze Yin Leung, Chit Kwong Chow, Ka Wah LiJohnny Ma, Wai Yuk Fung, Daniel Lee, Ming Yen Ng, Wilfred Hing Sang Wong, Hing Wai Tsang, Janette Kwok, Daniel Leung, Kin Lai Chung, Chun Bong Chow, Godfrey Chi Fung Chan, Wing Hang Leung, Kelvin Kai Wang To, Kwok Yung Yuen, Yu Lung Lau, Ian Chi Kei Wong, Patrick Ip

Pediatrics

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

BACKGROUND: Age-specific incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis/pericarditis among Hong Kong adolescents following Comirnaty vaccination. METHODS: This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination were analyzed. RESULTS: Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis/pericarditis was 18.52 (95% confidence interval [CI], 11.67-29.01) per 100 000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12-9.51) and 21.22 (95% CI, 13.78-32.28 per 100 000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38-12.53) and 37.32 (95% CI, 26.98-51.25) per 100 000 persons vaccinated. CONCLUSIONS: There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose.

Original language	English (US)
Pages (from-to)	673-681
Number of pages	9
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	75
Issue number	4
DOIs	https://doi.org/10.1093/cid/ciab989
State	Published - Sep 10 2022

Keywords

Comirnaty
Hong Kong
adolescents
myocarditis
pericarditis

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/cid/ciab989

Cite this

Chua, G. T., Kwan, M. Y. W., Chui, C. S. L., Smith, R. D., Cheung, E. C. L., Ma, T., Leung, M. T. Y., Tsao, S. S. L., Kan, E., Ng, W. K. C., Chan, V. C. M., Tai, S. M., Yu, T. C., Lee, K. P., Wong, J. S. C., Lin, Y. K., Shek, C. C., Leung, A. S. Y., Chow, C. K., ... Ip, P. (2022). Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 75(4), 673-681. https://doi.org/10.1093/cid/ciab989

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title = "Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination",

abstract = "BACKGROUND: Age-specific incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis/pericarditis among Hong Kong adolescents following Comirnaty vaccination. METHODS: This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination were analyzed. RESULTS: Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis/pericarditis was 18.52 (95% confidence interval [CI], 11.67-29.01) per 100 000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12-9.51) and 21.22 (95% CI, 13.78-32.28 per 100 000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38-12.53) and 37.32 (95% CI, 26.98-51.25) per 100 000 persons vaccinated. CONCLUSIONS: There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose.",

keywords = "Comirnaty, Hong Kong, adolescents, myocarditis, pericarditis",

author = "Chua, {Gilbert T.} and Kwan, {Mike Yat Wah} and Chui, {Celine S.L.} and Smith, {Robert David} and Cheung, {Edmund Chi Lok} and Tian Ma and Leung, {Miriam T.Y.} and Tsao, {Sabrina Siu Ling} and Elaine Kan and Ng, {Wing Kei Carol} and Chan, {Victor Chi Man} and Tai, {Shuk Mui} and Yu, {Tak Ching} and Lee, {Kwok Piu} and Wong, {Joshua Sung Chih} and Lin, {Ying Kit} and Shek, {Chi Chiu} and Leung, {Agnes Sze Yin} and Chow, {Chit Kwong} and Li, {Ka Wah} and Johnny Ma and Fung, {Wai Yuk} and Daniel Lee and Ng, {Ming Yen} and Wong, {Wilfred Hing Sang} and Tsang, {Hing Wai} and Janette Kwok and Daniel Leung and Chung, {Kin Lai} and Chow, {Chun Bong} and Chan, {Godfrey Chi Fung} and Leung, {Wing Hang} and To, {Kelvin Kai Wang} and Yuen, {Kwok Yung} and Lau, {Yu Lung} and Wong, {Ian Chi Kei} and Patrick Ip",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.",

year = "2022",

month = sep,

day = "10",

doi = "10.1093/cid/ciab989",

language = "English (US)",

volume = "75",

pages = "673--681",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "4",

}

Chua, GT, Kwan, MYW, Chui, CSL, Smith, RD, Cheung, ECL, Ma, T, Leung, MTY, Tsao, SSL, Kan, E, Ng, WKC, Chan, VCM, Tai, SM, Yu, TC, Lee, KP, Wong, JSC, Lin, YK, Shek, CC, Leung, ASY, Chow, CK, Li, KW, Ma, J, Fung, WY, Lee, D, Ng, MY, Wong, WHS, Tsang, HW, Kwok, J, Leung, D, Chung, KL, Chow, CB, Chan, GCF, Leung, WH, To, KKW, Yuen, KY, Lau, YL, Wong, ICK & Ip, P 2022, 'Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 75, no. 4, pp. 673-681. https://doi.org/10.1093/cid/ciab989

Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination. / Chua, Gilbert T.; Kwan, Mike Yat Wah; Chui, Celine S.L. et al.
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 75, No. 4, 10.09.2022, p. 673-681.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination

AU - Chua, Gilbert T.

AU - Kwan, Mike Yat Wah

AU - Chui, Celine S.L.

AU - Smith, Robert David

AU - Cheung, Edmund Chi Lok

AU - Ma, Tian

AU - Leung, Miriam T.Y.

AU - Tsao, Sabrina Siu Ling

AU - Kan, Elaine

AU - Ng, Wing Kei Carol

AU - Chan, Victor Chi Man

AU - Tai, Shuk Mui

AU - Yu, Tak Ching

AU - Lee, Kwok Piu

AU - Wong, Joshua Sung Chih

AU - Lin, Ying Kit

AU - Shek, Chi Chiu

AU - Leung, Agnes Sze Yin

AU - Chow, Chit Kwong

AU - Li, Ka Wah

AU - Ma, Johnny

AU - Fung, Wai Yuk

AU - Lee, Daniel

AU - Ng, Ming Yen

AU - Wong, Wilfred Hing Sang

AU - Tsang, Hing Wai

AU - Kwok, Janette

AU - Leung, Daniel

AU - Chung, Kin Lai

AU - Chow, Chun Bong

AU - Chan, Godfrey Chi Fung

AU - Leung, Wing Hang

AU - To, Kelvin Kai Wang

AU - Yuen, Kwok Yung

AU - Lau, Yu Lung

AU - Wong, Ian Chi Kei

AU - Ip, Patrick

PY - 2022/9/10

Y1 - 2022/9/10

N2 - BACKGROUND: Age-specific incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis/pericarditis among Hong Kong adolescents following Comirnaty vaccination. METHODS: This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination were analyzed. RESULTS: Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis/pericarditis was 18.52 (95% confidence interval [CI], 11.67-29.01) per 100 000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12-9.51) and 21.22 (95% CI, 13.78-32.28 per 100 000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38-12.53) and 37.32 (95% CI, 26.98-51.25) per 100 000 persons vaccinated. CONCLUSIONS: There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose.

AB - BACKGROUND: Age-specific incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination in Asia is lacking. This study aimed to study the clinical characteristics and incidence of acute myocarditis/pericarditis among Hong Kong adolescents following Comirnaty vaccination. METHODS: This is a population cohort study in Hong Kong that monitored adverse events following immunization through a pharmacovigilance system for coronavirus disease 2019 (COVID-19) vaccines. All adolescents aged between 12 and 17 years following Comirnaty vaccination were monitored under the COVID-19 vaccine adverse event response and evaluation program. The clinical characteristics and overall incidence of acute myocarditis/pericarditis in adolescents following Comirnaty vaccination were analyzed. RESULTS: Between 14 June 2021 and 4 September 2021, 33 Chinese adolescents who developed acute myocarditis/pericarditis following Comirnaty vaccination were identified. In total, 29 (87.88%) were male and 4 (12.12%) were female, with a median age of 15.25 years. And 27 (81.82%) and 6 (18.18%) cases developed acute myocarditis/pericarditis after receiving the second and first dose, respectively. All cases are mild and required only conservative management. The overall incidence of acute myocarditis/pericarditis was 18.52 (95% confidence interval [CI], 11.67-29.01) per 100 000 persons vaccinated. The incidence after the first and second doses were 3.37 (95% CI, 1.12-9.51) and 21.22 (95% CI, 13.78-32.28 per 100 000 persons vaccinated, respectively. Among male adolescents, the incidence after the first and second doses were 5.57 (95% CI, 2.38-12.53) and 37.32 (95% CI, 26.98-51.25) per 100 000 persons vaccinated. CONCLUSIONS: There is a significant increase in the risk of acute myocarditis/pericarditis following Comirnaty vaccination among Chinese male adolescents, especially after the second dose.

KW - Comirnaty

KW - Hong Kong

KW - adolescents

KW - myocarditis

KW - pericarditis

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U2 - 10.1093/cid/ciab989

DO - 10.1093/cid/ciab989

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AN - SCOPUS:85138128215

SN - 1058-4838

VL - 75

SP - 673

EP - 681

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 4

ER -

Epidemiology of Acute Myocarditis/Pericarditis in Hong Kong Adolescents Following Comirnaty Vaccination

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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