Epidermal growth factor receptor inhibitors in the treatment of nonmelanoma skin cancers

Misbah H. Khan*, Murad Alam, Simon S Yoo

*Corresponding author for this work

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

BACKGROUND A better understanding of the molecular pathways that characterize cell growth, apoptosis, angiogenesis, and invasion has provided novel targets in cancer therapy. Epidermal growth factor receptor (EGFR)-mediated signal transduction has been one of the most studied pathways in carcinogenesis. The phosphorylation of EGFR activates multiple biological processes, including apoptosis, differentiation, cellular proliferation, motility, invasion, adhesion, DNA repair, and survival. EGFR is a transmembrane tyrosine kinase receptor involved in the proliferation and survival of cancer cells. EGFR is the first molecular target against which monoclonal antibodies have been developed for cancer therapy. OBJECTIVE To review the mechanisms underlying the effects of EGFR in nonmelanoma skin cancer (NMSC) and their potential role as targeted therapies in the treatment thereof. CONCLUSIONS EGFR plays an important role in tumorigenesis of NMSC, especially metastatic squamous cell carcinoma, via mechanisms similar to those of other visceral tumors. Pharmacologic inhibitors of EGFR pathway of tumor production may offer an effective therapeutic strategy to block tumor growth.

Original languageEnglish (US)
Pages (from-to)1199-1209
Number of pages11
JournalDermatologic Surgery
Volume37
Issue number9
DOIs
StatePublished - Sep 1 2011

Fingerprint

Skin Neoplasms
Epidermal Growth Factor Receptor
Neoplasms
Carcinogenesis
Apoptosis
Biological Phenomena
Receptor Protein-Tyrosine Kinases
Therapeutics
Growth
DNA Repair
Squamous Cell Carcinoma
Signal Transduction
Cell Survival
Monoclonal Antibodies
Phosphorylation
Cell Proliferation

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

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abstract = "BACKGROUND A better understanding of the molecular pathways that characterize cell growth, apoptosis, angiogenesis, and invasion has provided novel targets in cancer therapy. Epidermal growth factor receptor (EGFR)-mediated signal transduction has been one of the most studied pathways in carcinogenesis. The phosphorylation of EGFR activates multiple biological processes, including apoptosis, differentiation, cellular proliferation, motility, invasion, adhesion, DNA repair, and survival. EGFR is a transmembrane tyrosine kinase receptor involved in the proliferation and survival of cancer cells. EGFR is the first molecular target against which monoclonal antibodies have been developed for cancer therapy. OBJECTIVE To review the mechanisms underlying the effects of EGFR in nonmelanoma skin cancer (NMSC) and their potential role as targeted therapies in the treatment thereof. CONCLUSIONS EGFR plays an important role in tumorigenesis of NMSC, especially metastatic squamous cell carcinoma, via mechanisms similar to those of other visceral tumors. Pharmacologic inhibitors of EGFR pathway of tumor production may offer an effective therapeutic strategy to block tumor growth.",
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Epidermal growth factor receptor inhibitors in the treatment of nonmelanoma skin cancers. / Khan, Misbah H.; Alam, Murad; Yoo, Simon S.

In: Dermatologic Surgery, Vol. 37, No. 9, 01.09.2011, p. 1199-1209.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Epidermal growth factor receptor inhibitors in the treatment of nonmelanoma skin cancers

AU - Khan, Misbah H.

AU - Alam, Murad

AU - Yoo, Simon S

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N2 - BACKGROUND A better understanding of the molecular pathways that characterize cell growth, apoptosis, angiogenesis, and invasion has provided novel targets in cancer therapy. Epidermal growth factor receptor (EGFR)-mediated signal transduction has been one of the most studied pathways in carcinogenesis. The phosphorylation of EGFR activates multiple biological processes, including apoptosis, differentiation, cellular proliferation, motility, invasion, adhesion, DNA repair, and survival. EGFR is a transmembrane tyrosine kinase receptor involved in the proliferation and survival of cancer cells. EGFR is the first molecular target against which monoclonal antibodies have been developed for cancer therapy. OBJECTIVE To review the mechanisms underlying the effects of EGFR in nonmelanoma skin cancer (NMSC) and their potential role as targeted therapies in the treatment thereof. CONCLUSIONS EGFR plays an important role in tumorigenesis of NMSC, especially metastatic squamous cell carcinoma, via mechanisms similar to those of other visceral tumors. Pharmacologic inhibitors of EGFR pathway of tumor production may offer an effective therapeutic strategy to block tumor growth.

AB - BACKGROUND A better understanding of the molecular pathways that characterize cell growth, apoptosis, angiogenesis, and invasion has provided novel targets in cancer therapy. Epidermal growth factor receptor (EGFR)-mediated signal transduction has been one of the most studied pathways in carcinogenesis. The phosphorylation of EGFR activates multiple biological processes, including apoptosis, differentiation, cellular proliferation, motility, invasion, adhesion, DNA repair, and survival. EGFR is a transmembrane tyrosine kinase receptor involved in the proliferation and survival of cancer cells. EGFR is the first molecular target against which monoclonal antibodies have been developed for cancer therapy. OBJECTIVE To review the mechanisms underlying the effects of EGFR in nonmelanoma skin cancer (NMSC) and their potential role as targeted therapies in the treatment thereof. CONCLUSIONS EGFR plays an important role in tumorigenesis of NMSC, especially metastatic squamous cell carcinoma, via mechanisms similar to those of other visceral tumors. Pharmacologic inhibitors of EGFR pathway of tumor production may offer an effective therapeutic strategy to block tumor growth.

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