Epididymal cystadenomas in von hippel-lindau disease showing increased activity on 68Ga DOTATATE PET/CT

Georgios Z. Papadakis; Corina Millo; Samira M. Sadowski; Ulas Bagci; Nicholas J. Patronas

doi:10.1097/RLU.0000000000001314

Epididymal cystadenomas in von hippel-lindau disease showing increased activity on ⁶⁸Ga DOTATATE PET/CT

Georgios Z. Papadakis, Corina Millo, Samira M. Sadowski, Ulas Bagci, Nicholas J. Patronas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

von Hippel-Lindau (VHL) disease is a familial cancer syndrome characterized by the development of a variety of malignant and benign tumors, including epididymal cystadenomas. We report a case of a VHL patient with bilateral epididymal cystadenomas who was evaluated with ⁶⁸Ga DOTATATE PET/CT, showing intensely increased activity (SUVmax, 21.6) associated with the epididymal cystadenomas, indicating cell-surface overexpression of somatostatin receptors. The presented case supports the usefulness of somatostatin receptor imaging using ⁶⁸Ga DOTA-conjugated peptides for detection and follow-up of VHL manifestations, as well as surveillance of asymptomatic gene carriers.

Original language	English (US)
Pages (from-to)	781-782
Number of pages	2
Journal	Clinical nuclear medicine
Volume	41
Issue number	10
DOIs	https://doi.org/10.1097/RLU.0000000000001314
State	Published - Jul 23 2016
Externally published	Yes

Keywords

Cystadenomas
Epididymal
Ga DOTATATE PET/CT
Somatostatin receptors imaging
Von Hippel-Lindau (VHL) disease

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1097/RLU.0000000000001314

Cite this

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title = "Epididymal cystadenomas in von hippel-lindau disease showing increased activity on 68Ga DOTATATE PET/CT",

abstract = "von Hippel-Lindau (VHL) disease is a familial cancer syndrome characterized by the development of a variety of malignant and benign tumors, including epididymal cystadenomas. We report a case of a VHL patient with bilateral epididymal cystadenomas who was evaluated with 68Ga DOTATATE PET/CT, showing intensely increased activity (SUVmax, 21.6) associated with the epididymal cystadenomas, indicating cell-surface overexpression of somatostatin receptors. The presented case supports the usefulness of somatostatin receptor imaging using 68Ga DOTA-conjugated peptides for detection and follow-up of VHL manifestations, as well as surveillance of asymptomatic gene carriers.",

keywords = "Cystadenomas, Epididymal, Ga DOTATATE PET/CT, Somatostatin receptors imaging, Von Hippel-Lindau (VHL) disease",

author = "Papadakis, {Georgios Z.} and Corina Millo and Sadowski, {Samira M.} and Ulas Bagci and Patronas, {Nicholas J.}",

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AU - Papadakis, Georgios Z.

AU - Millo, Corina

AU - Sadowski, Samira M.

AU - Bagci, Ulas

AU - Patronas, Nicholas J.

PY - 2016/7/23

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AB - von Hippel-Lindau (VHL) disease is a familial cancer syndrome characterized by the development of a variety of malignant and benign tumors, including epididymal cystadenomas. We report a case of a VHL patient with bilateral epididymal cystadenomas who was evaluated with 68Ga DOTATATE PET/CT, showing intensely increased activity (SUVmax, 21.6) associated with the epididymal cystadenomas, indicating cell-surface overexpression of somatostatin receptors. The presented case supports the usefulness of somatostatin receptor imaging using 68Ga DOTA-conjugated peptides for detection and follow-up of VHL manifestations, as well as surveillance of asymptomatic gene carriers.

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