Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study

Tao Gao; Yinan Zheng; Brian T. Joyce; Minjung Kho; James G. Terry; Jun Wang; Drew Nannini; John Jeffrey Carr; Sangeeta Nair; Kai Zhang; Wei Zhao; David R. Jacobs; Pamela J. Schreiner; Philip Greenland; Donald Lloyd-Jones; Jennifer A. Smith; Lifang Hou

doi:10.1093/gerona/glad261

Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study

Tao Gao^*, Yinan Zheng, Brian T. Joyce, Minjung Kho, James G. Terry, Jun Wang, Drew Nannini, John Jeffrey Carr, Sangeeta Nair, Kai Zhang, Wei Zhao, David R. Jacobs, Pamela J. Schreiner, Philip Greenland, Donald Lloyd-Jones, Jennifer A. Smith, Lifang Hou

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown. Methods: We estimated measures of GAA in 1 118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000–2001) and 20 (2005–2006). Abdominal muscle composition was measured using CT scans at the Y25 (2010–2011) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements. Results: In the CARDIA study, each 1-year higher GAA was associated with an average 1.1% (95% confidence interval [CI]: 0.6%, 1.5%) higher intermuscular adipose tissue (IMAT) volume for abdominal muscles. Each 1-year higher GAA was associated with an average −0.089 Hounsfield unit (HU; 95% CI: −0.146, −0.032) lower lean muscle attenuation and an average −0.049 HU (95% CI: −0.092, −0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only. Conclusions: Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.

Original language	English (US)
Article number	glad261
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	79
Issue number	3
DOIs	https://doi.org/10.1093/gerona/glad261
State	Published - Mar 1 2024

Funding

The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201800005I and HHSN268201800007I), Northwestern University (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and Kaiser Foundation Research Institute (HHSN268201800004I). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intraagency agreement between NIA and NHLBI (AG0005). The CT work and analysis were funded in part by R01 HL098445/HL/NHLBI NIH HHS, Wake Forest University Health Sciences and Vanderbilt University, PI: Dr. J. J. C. The laboratory work and analytical component were funded by American Heart Association (17SFRN33700278 and 14SFRN20790000, Northwestern University, PI: Dr. L. H.) and NIA (R01AG069120 and R01AG081244, PI: Dr. L. H.).

Keywords

GrimAge acceleration
Intermuscular adipose tissue
Lean muscle attenuation

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Gao, T., Zheng, Y., Joyce, B. T., Kho, M., Terry, J. G., Wang, J., Nannini, D., Carr, J. J., Nair, S., Zhang, K., Zhao, W., Jacobs, D. R., Schreiner, P. J., Greenland, P., Lloyd-Jones, D., Smith, J. A., & Hou, L. (2024). Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 79(3), Article glad261. https://doi.org/10.1093/gerona/glad261

@article{c6cd23b7063b45cfa23adbb70367ef88,

title = "Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study",

abstract = "Background: GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown. Methods: We estimated measures of GAA in 1 118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000–2001) and 20 (2005–2006). Abdominal muscle composition was measured using CT scans at the Y25 (2010–2011) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements. Results: In the CARDIA study, each 1-year higher GAA was associated with an average 1.1% (95% confidence interval [CI]: 0.6%, 1.5%) higher intermuscular adipose tissue (IMAT) volume for abdominal muscles. Each 1-year higher GAA was associated with an average −0.089 Hounsfield unit (HU; 95% CI: −0.146, −0.032) lower lean muscle attenuation and an average −0.049 HU (95% CI: −0.092, −0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only. Conclusions: Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.",

keywords = "GrimAge acceleration, Intermuscular adipose tissue, Lean muscle attenuation",

author = "Tao Gao and Yinan Zheng and Joyce, {Brian T.} and Minjung Kho and Terry, {James G.} and Jun Wang and Drew Nannini and Carr, {John Jeffrey} and Sangeeta Nair and Kai Zhang and Wei Zhao and Jacobs, {David R.} and Schreiner, {Pamela J.} and Philip Greenland and Donald Lloyd-Jones and Smith, {Jennifer A.} and Lifang Hou",

year = "2024",

month = mar,

day = "1",

doi = "10.1093/gerona/glad261",

language = "English (US)",

volume = "79",

journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",

issn = "1079-5006",

publisher = "Oxford University Press",

number = "3",

}

Gao, T , Zheng, Y , Joyce, BT, Kho, M, Terry, JG, Wang, J, Nannini, D, Carr, JJ, Nair, S, Zhang, K, Zhao, W, Jacobs, DR, Schreiner, PJ, Greenland, P, Lloyd-Jones, D, Smith, JA & Hou, L 2024, 'Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 79, no. 3, glad261. https://doi.org/10.1093/gerona/glad261

TY - JOUR

T1 - Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study

AU - Gao, Tao

AU - Zheng, Yinan

AU - Joyce, Brian T.

AU - Kho, Minjung

AU - Terry, James G.

AU - Wang, Jun

AU - Nannini, Drew

AU - Carr, John Jeffrey

AU - Nair, Sangeeta

AU - Zhang, Kai

AU - Zhao, Wei

AU - Jacobs, David R.

AU - Schreiner, Pamela J.

AU - Greenland, Philip

AU - Lloyd-Jones, Donald

AU - Smith, Jennifer A.

AU - Hou, Lifang

PY - 2024/3/1

Y1 - 2024/3/1

N2 - Background: GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown. Methods: We estimated measures of GAA in 1 118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000–2001) and 20 (2005–2006). Abdominal muscle composition was measured using CT scans at the Y25 (2010–2011) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements. Results: In the CARDIA study, each 1-year higher GAA was associated with an average 1.1% (95% confidence interval [CI]: 0.6%, 1.5%) higher intermuscular adipose tissue (IMAT) volume for abdominal muscles. Each 1-year higher GAA was associated with an average −0.089 Hounsfield unit (HU; 95% CI: −0.146, −0.032) lower lean muscle attenuation and an average −0.049 HU (95% CI: −0.092, −0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only. Conclusions: Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.

AB - Background: GrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown. Methods: We estimated measures of GAA in 1 118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000–2001) and 20 (2005–2006). Abdominal muscle composition was measured using CT scans at the Y25 (2010–2011) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements. Results: In the CARDIA study, each 1-year higher GAA was associated with an average 1.1% (95% confidence interval [CI]: 0.6%, 1.5%) higher intermuscular adipose tissue (IMAT) volume for abdominal muscles. Each 1-year higher GAA was associated with an average −0.089 Hounsfield unit (HU; 95% CI: −0.146, −0.032) lower lean muscle attenuation and an average −0.049 HU (95% CI: −0.092, −0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only. Conclusions: Higher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.

KW - GrimAge acceleration

KW - Intermuscular adipose tissue

KW - Lean muscle attenuation

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U2 - 10.1093/gerona/glad261

DO - 10.1093/gerona/glad261

M3 - Article

C2 - 37956337

AN - SCOPUS:85185828369

SN - 1079-5006

VL - 79

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 3

M1 - glad261

ER -

Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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