Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma

Marc Alard Morgan, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

In this issue of Cancer Cell, McBride and colleagues report that the synovial sarcoma SS18-SSX fusion drives BAF complex recruitment to bivalent domains repressed by PRC2 complex to orchestrate aberrant transcriptional activation. Redistribution of BAF localization is a major driver of synovial sarcoma proliferation and presents a promising therapeutic target. In this issue of Cancer Cell, McBride and colleagues report that the synovial sarcoma SS18-SSX fusion drives BAF complex recruitment to bivalent domains repressed by PRC2 complex to orchestrate aberrant transcriptional activation. Redistribution of BAF localization is a major driver of synovial sarcoma proliferation and presents a promising therapeutic target.

Original languageEnglish (US)
Pages (from-to)951-953
Number of pages3
JournalCancer Cell
Volume33
Issue number6
DOIs
StatePublished - Jun 11 2018

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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