Epigenetic Control of Regulatory T Cell Stability and Function: Implications for Translation

Anthony M. Joudi, Carla P. Reyes Flores, Benjamin D. Singer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


FoxP3+ regulatory T (Treg) cells maintain immune homeostasis, promote self-tolerance, and have an emerging role in resolving acute inflammation, providing tissue protection, and repairing tissue damage. Some data suggest that FoxP3+ T cells are plastic, exhibiting susceptibility to losing their function in inflammatory cytokine-rich microenvironments and paradoxically contributing to inflammatory pathology. As a result, plasticity may represent a barrier to Treg cell immunotherapy. Here, we discuss controversies surrounding Treg cell plasticity and explore determinants of Treg cell stability in inflammatory microenvironments, focusing on epigenetic mechanisms that clinical protocols could leverage to enhance efficacy and limit toxicity of Treg cell-based therapeutics.

Original languageEnglish (US)
Article number861607
JournalFrontiers in immunology
StatePublished - Mar 2 2022


  • DNA methylation
  • epigenetics
  • inflammation
  • plasticity
  • regulatory T cells
  • therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Epigenetic Control of Regulatory T Cell Stability and Function: Implications for Translation'. Together they form a unique fingerprint.

Cite this