Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid

Niraj Shenoy

doi:10.1080/23723556.2019.1595309

Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid

Niraj Shenoy^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the findings and their translational significance, and important considerations while testing Ascorbic acid as an anti-cancer agent. Abbreviations-ccRCC: clear cell renal cell carcinoma; TET: Ten-Eleven Translocation; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; L2HG: l-2-hydroxyglutarate; L2HGDH: l-2-hydroxyglutarate dehydrogenase; 2-OG: 2-Oxoglutarate; AA: Ascorbic acid.

Original language	English (US)
Article number	1595309
Journal	Molecular and Cellular Oncology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2019.1595309
State	Published - May 4 2019

Keywords

Ascorbic acid
cancer
epigenetics
hydroxymethylcytosine
kidney cancer

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/23723556.2019.1595309

Cite this

@article{ef1fa95d672943bdbf493f2a11f1a4ab,

title = "Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid",

abstract = "Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the findings and their translational significance, and important considerations while testing Ascorbic acid as an anti-cancer agent. Abbreviations-ccRCC: clear cell renal cell carcinoma; TET: Ten-Eleven Translocation; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; L2HG: l-2-hydroxyglutarate; L2HGDH: l-2-hydroxyglutarate dehydrogenase; 2-OG: 2-Oxoglutarate; AA: Ascorbic acid.",

keywords = "Ascorbic acid, cancer, epigenetics, hydroxymethylcytosine, kidney cancer",

author = "Niraj Shenoy",

note = "Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.",

year = "2019",

month = may,

day = "4",

doi = "10.1080/23723556.2019.1595309",

language = "English (US)",

volume = "6",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid

AU - Shenoy, Niraj

PY - 2019/5/4

Y1 - 2019/5/4

N2 - Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the findings and their translational significance, and important considerations while testing Ascorbic acid as an anti-cancer agent. Abbreviations-ccRCC: clear cell renal cell carcinoma; TET: Ten-Eleven Translocation; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; L2HG: l-2-hydroxyglutarate; L2HGDH: l-2-hydroxyglutarate dehydrogenase; 2-OG: 2-Oxoglutarate; AA: Ascorbic acid.

AB - Our recently published study uncovered mechanisms and prognostic impact of aberrant DNA methylation/hydroxymethylation in clear cell renal cell carcinoma, and comprehensively explored the potential of Ascorbic acid in reversing the epigenetic aberrancy. This article provides a summary of the findings and their translational significance, and important considerations while testing Ascorbic acid as an anti-cancer agent. Abbreviations-ccRCC: clear cell renal cell carcinoma; TET: Ten-Eleven Translocation; 5mC: 5-methylcytosine; 5hmC: 5-hydroxymethylcytosine; L2HG: l-2-hydroxyglutarate; L2HGDH: l-2-hydroxyglutarate dehydrogenase; 2-OG: 2-Oxoglutarate; AA: Ascorbic acid.

KW - Ascorbic acid

KW - cancer

KW - epigenetics

KW - hydroxymethylcytosine

KW - kidney cancer

UR - http://www.scopus.com/inward/record.url?scp=85063937084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063937084&partnerID=8YFLogxK

U2 - 10.1080/23723556.2019.1595309

DO - 10.1080/23723556.2019.1595309

M3 - Article

C2 - 31131312

AN - SCOPUS:85063937084

SN - 2372-3556

VL - 6

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 3

M1 - 1595309

ER -

Epigenetic dysregulation by aberrant metabolism in renal cell carcinoma can be reversed with Ascorbic acid

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this