Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies

Eleonore Maury, Rintaro Hashizume*

*Corresponding author for this work

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin remodeling processes. This review will focus on the mechanisms underlying this reprogramming and, specifically, on the role of histone modification in chromatin machinery and the modifications in epigenetic processes occurring in brain cancer, with a specific focus on epigenetic therapies for pediatric brain tumors.

Original languageEnglish (US)
Pages (from-to)353-369
Number of pages17
JournalEpigenetics
Volume12
Issue number5
DOIs
Publication statusPublished - May 4 2017

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Keywords

  • Acetylation
  • DIPG
  • brain tumor
  • demethylase
  • epigenetic
  • histone
  • methylation
  • methyltransferase
  • pediatric

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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