Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies

Eleonore Maury; Rintaro Hashizume

doi:10.1080/15592294.2016.1278095

Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies

Eleonore Maury, Rintaro Hashizume^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin remodeling processes. This review will focus on the mechanisms underlying this reprogramming and, specifically, on the role of histone modification in chromatin machinery and the modifications in epigenetic processes occurring in brain cancer, with a specific focus on epigenetic therapies for pediatric brain tumors.

Original language	English (US)
Pages (from-to)	353-369
Number of pages	17
Journal	Epigenetics
Volume	12
Issue number	5
DOIs	https://doi.org/10.1080/15592294.2016.1278095
State	Published - May 4 2017

Keywords

Acetylation
DIPG
brain tumor
demethylase
epigenetic
histone
methylation
methyltransferase
pediatric

ASJC Scopus subject areas

Molecular Biology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/15592294.2016.1278095

Cite this

@article{dcbb01fdac0f4c7dadc7823d7efba432,

title = "Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies",

abstract = "Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin remodeling processes. This review will focus on the mechanisms underlying this reprogramming and, specifically, on the role of histone modification in chromatin machinery and the modifications in epigenetic processes occurring in brain cancer, with a specific focus on epigenetic therapies for pediatric brain tumors.",

keywords = "Acetylation, DIPG, brain tumor, demethylase, epigenetic, histone, methylation, methyltransferase, pediatric",

author = "Eleonore Maury and Rintaro Hashizume",

note = "Publisher Copyright: {\textcopyright} 2017 Taylor & Francis Group, LLC.",

year = "2017",

month = may,

day = "4",

doi = "10.1080/15592294.2016.1278095",

language = "English (US)",

volume = "12",

pages = "353--369",

journal = "Epigenetics",

issn = "1559-2294",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

TY - JOUR

T1 - Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors

T2 - Insight into epigenetic therapies

AU - Maury, Eleonore

AU - Hashizume, Rintaro

PY - 2017/5/4

Y1 - 2017/5/4

N2 - Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin remodeling processes. This review will focus on the mechanisms underlying this reprogramming and, specifically, on the role of histone modification in chromatin machinery and the modifications in epigenetic processes occurring in brain cancer, with a specific focus on epigenetic therapies for pediatric brain tumors.

AB - Malignancies are characterized by the reprogramming of epigenetic patterns. This reprogramming includes gains or losses in DNA methylation and disruption of normal patterns of covalent histone modifications, which are associated with changes in chromatin remodeling processes. This review will focus on the mechanisms underlying this reprogramming and, specifically, on the role of histone modification in chromatin machinery and the modifications in epigenetic processes occurring in brain cancer, with a specific focus on epigenetic therapies for pediatric brain tumors.

KW - Acetylation

KW - DIPG

KW - brain tumor

KW - demethylase

KW - epigenetic

KW - histone

KW - methylation

KW - methyltransferase

KW - pediatric

UR - http://www.scopus.com/inward/record.url?scp=85014800358&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014800358&partnerID=8YFLogxK

U2 - 10.1080/15592294.2016.1278095

DO - 10.1080/15592294.2016.1278095

M3 - Article

C2 - 28059591

AN - SCOPUS:85014800358

SN - 1559-2294

VL - 12

SP - 353

EP - 369

JO - Epigenetics

JF - Epigenetics

IS - 5

ER -

Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this