Abstract
The epigenetic modifications of histones are versatile marks that are intimately connected to development and disease pathogenesis including human cancers. In this review, we will discuss the many different types of histone modifications and the biological processes with which they are involved. Specifically, we review the enzymatic machineries and modifications that are involved in cancer development and progression, and how to apply currently available small molecule inhibitors for histone modifiers as tool compounds to study the functional significance of histone modifications and their clinical implications.
| Original language | English (US) |
|---|---|
| Article number | 245 |
| Journal | Genome biology |
| Volume | 20 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 20 2019 |
Funding
Z.Z. is supported in part by NIH/NCI training grant T32 CA070085 and ALSF Young Investigator Award co-funded by Alex's Lemonade Stand Foundation and Northwestern Mutual. Studies are supported in part by the generous Outstanding Investigator Award R35-CA197569 from the National Cancer Institute to A.S.
ASJC Scopus subject areas
- Genetics
- Ecology, Evolution, Behavior and Systematics
- Cell Biology
