Epigenetic Regulation of Cancer Immune Cells

Diego M. Avella Patino; Vijay Radhakrishnan; Kanve N. Suvilesh; Yariswamy Manjunath; Guangfu Li; Eric T. Kimchi; Kevin F. Staveley-O'Carroll; Wesley C. Warren; Jussuf T. Kaifi; Jonathan B. Mitchem

doi:10.1016/j.semcancer.2021.06.022

Epigenetic Regulation of Cancer Immune Cells

Diego M. Avella Patino^*, Vijay Radhakrishnan, Kanve N. Suvilesh, Yariswamy Manjunath, Guangfu Li, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Wesley C. Warren, Jussuf T. Kaifi, Jonathan B. Mitchem

^*Corresponding author for this work

Surgery, Thoracic Surgery Division

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

The epigenetic regulation of immune response involves reversible and heritable changes that do not alter the DNA sequence. Though there have been extensive studies accomplished relating to epigenetic changes in cancer cells, recent focus has been shifted on epigenetic-mediated changes in the immune cells including T cells, Macrophages, Natural Killer cells and anti-tumor immune responses. This review compiles the most relevant and recent literature related to the role of epigenetic mechanisms including DNA methylation and histone modifications in immune cells of wide range of cancers. We also include recent research with respect to role of the most relevant transcription factors that epigenetically control the anti-tumor immune response. Finally, a statement of future direction that promises to look forward for strategies to improve immunotherapy in cancer.

Original language	English (US)
Pages (from-to)	377-383
Number of pages	7
Journal	Seminars in Cancer Biology
Volume	83
DOIs	https://doi.org/10.1016/j.semcancer.2021.06.022
State	Published - Aug 2022

Funding

This study was supported by a Mizzou Advantage Interdisciplinary Research Grant (MAIRG) (D.A.P., G.L., and J.T.K). J.B.M. received funding from the Department of Veteran's AffairsK2BX004346-01A1. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veterans’ Affairs. The funding bodies had no role in study design, collection, analysis, interpretation of data or writing the manuscript. This study was supported by a Mizzou Advantage Interdisciplinary Research Grant (MAIRG) (D.A.P., G.L., and J.T.K). J.B.M. received funding from the Department of Veteran’s Affairs K2BX004346-01A1 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veterans’ Affairs. The funding bodies had no role in study design, collection, analysis, interpretation of data or writing the manuscript.

Keywords

DNA methylation
Epigenetics
Histone modification and antitumor immunity
Tumor infiltrated immune cells

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.semcancer.2021.06.022

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title = "Epigenetic Regulation of Cancer Immune Cells",

abstract = "The epigenetic regulation of immune response involves reversible and heritable changes that do not alter the DNA sequence. Though there have been extensive studies accomplished relating to epigenetic changes in cancer cells, recent focus has been shifted on epigenetic-mediated changes in the immune cells including T cells, Macrophages, Natural Killer cells and anti-tumor immune responses. This review compiles the most relevant and recent literature related to the role of epigenetic mechanisms including DNA methylation and histone modifications in immune cells of wide range of cancers. We also include recent research with respect to role of the most relevant transcription factors that epigenetically control the anti-tumor immune response. Finally, a statement of future direction that promises to look forward for strategies to improve immunotherapy in cancer.",

keywords = "DNA methylation, Epigenetics, Histone modification and antitumor immunity, Tumor infiltrated immune cells",

author = "{Avella Patino}, {Diego M.} and Vijay Radhakrishnan and Suvilesh, {Kanve N.} and Yariswamy Manjunath and Guangfu Li and Kimchi, {Eric T.} and Staveley-O'Carroll, {Kevin F.} and Warren, {Wesley C.} and Kaifi, {Jussuf T.} and Mitchem, {Jonathan B.}",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2022",

month = aug,

doi = "10.1016/j.semcancer.2021.06.022",

language = "English (US)",

volume = "83",

pages = "377--383",

journal = "Seminars in Cancer Biology",

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T1 - Epigenetic Regulation of Cancer Immune Cells

AU - Avella Patino, Diego M.

AU - Radhakrishnan, Vijay

AU - Suvilesh, Kanve N.

AU - Manjunath, Yariswamy

AU - Li, Guangfu

AU - Kimchi, Eric T.

AU - Staveley-O'Carroll, Kevin F.

AU - Warren, Wesley C.

AU - Kaifi, Jussuf T.

AU - Mitchem, Jonathan B.

PY - 2022/8

Y1 - 2022/8

N2 - The epigenetic regulation of immune response involves reversible and heritable changes that do not alter the DNA sequence. Though there have been extensive studies accomplished relating to epigenetic changes in cancer cells, recent focus has been shifted on epigenetic-mediated changes in the immune cells including T cells, Macrophages, Natural Killer cells and anti-tumor immune responses. This review compiles the most relevant and recent literature related to the role of epigenetic mechanisms including DNA methylation and histone modifications in immune cells of wide range of cancers. We also include recent research with respect to role of the most relevant transcription factors that epigenetically control the anti-tumor immune response. Finally, a statement of future direction that promises to look forward for strategies to improve immunotherapy in cancer.

AB - The epigenetic regulation of immune response involves reversible and heritable changes that do not alter the DNA sequence. Though there have been extensive studies accomplished relating to epigenetic changes in cancer cells, recent focus has been shifted on epigenetic-mediated changes in the immune cells including T cells, Macrophages, Natural Killer cells and anti-tumor immune responses. This review compiles the most relevant and recent literature related to the role of epigenetic mechanisms including DNA methylation and histone modifications in immune cells of wide range of cancers. We also include recent research with respect to role of the most relevant transcription factors that epigenetically control the anti-tumor immune response. Finally, a statement of future direction that promises to look forward for strategies to improve immunotherapy in cancer.

KW - DNA methylation

KW - Epigenetics

KW - Histone modification and antitumor immunity

KW - Tumor infiltrated immune cells

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DO - 10.1016/j.semcancer.2021.06.022

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SN - 1044-579X

VL - 83

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JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

Epigenetic Regulation of Cancer Immune Cells

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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