TY - JOUR
T1 - Epigenetic Regulation of Cancer Immune Cells
AU - Avella Patino, Diego M.
AU - Radhakrishnan, Vijay
AU - Suvilesh, Kanve N.
AU - Manjunath, Yariswamy
AU - Li, Guangfu
AU - Kimchi, Eric T.
AU - Staveley-O'Carroll, Kevin F.
AU - Warren, Wesley C.
AU - Kaifi, Jussuf T.
AU - Mitchem, Jonathan B.
N1 - Funding Information:
This study was supported by a Mizzou Advantage Interdisciplinary Research Grant (MAIRG) (D.A.P., G.L., and J.T.K). J.B.M. received funding from the Department of Veteran's AffairsK2BX004346-01A1. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veterans’ Affairs. The funding bodies had no role in study design, collection, analysis, interpretation of data or writing the manuscript.
Funding Information:
This study was supported by a Mizzou Advantage Interdisciplinary Research Grant (MAIRG) (D.A.P., G.L., and J.T.K). J.B.M. received funding from the Department of Veteran’s Affairs K2BX004346-01A1 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the Department of Veterans’ Affairs. The funding bodies had no role in study design, collection, analysis, interpretation of data or writing the manuscript.
Publisher Copyright:
© 2021
PY - 2022/8
Y1 - 2022/8
N2 - The epigenetic regulation of immune response involves reversible and heritable changes that do not alter the DNA sequence. Though there have been extensive studies accomplished relating to epigenetic changes in cancer cells, recent focus has been shifted on epigenetic-mediated changes in the immune cells including T cells, Macrophages, Natural Killer cells and anti-tumor immune responses. This review compiles the most relevant and recent literature related to the role of epigenetic mechanisms including DNA methylation and histone modifications in immune cells of wide range of cancers. We also include recent research with respect to role of the most relevant transcription factors that epigenetically control the anti-tumor immune response. Finally, a statement of future direction that promises to look forward for strategies to improve immunotherapy in cancer.
AB - The epigenetic regulation of immune response involves reversible and heritable changes that do not alter the DNA sequence. Though there have been extensive studies accomplished relating to epigenetic changes in cancer cells, recent focus has been shifted on epigenetic-mediated changes in the immune cells including T cells, Macrophages, Natural Killer cells and anti-tumor immune responses. This review compiles the most relevant and recent literature related to the role of epigenetic mechanisms including DNA methylation and histone modifications in immune cells of wide range of cancers. We also include recent research with respect to role of the most relevant transcription factors that epigenetically control the anti-tumor immune response. Finally, a statement of future direction that promises to look forward for strategies to improve immunotherapy in cancer.
KW - DNA methylation
KW - Epigenetics
KW - Histone modification and antitumor immunity
KW - Tumor infiltrated immune cells
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U2 - 10.1016/j.semcancer.2021.06.022
DO - 10.1016/j.semcancer.2021.06.022
M3 - Review article
C2 - 34182142
AN - SCOPUS:85109037202
SN - 1044-579X
VL - 83
SP - 377
EP - 383
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -
