Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: A neural developmental disease

Flor M. Mendez, Felipe J. Núñez, Maria B. Garcia-Fabiani, Santiago Haase, Stephen Carney, Jessica C. Gauss, Oren J. Becher, Pedro R. Lowenstein, Maria G. Castro*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Diffuse intrinsic pontine glioma (DIPG) is a rare but deadly pediatric brainstem tumor. To date, there is no effective therapy for DIPG. Transcriptomic analyses have revealed DIPGs have a distinct profile from other pediatric high-grade gliomas occurring in the cerebral hemispheres. These unique genomic characteristics coupled with the younger median age group suggest that DIPG has a developmental origin. The most frequent mutation in DIPG is a lysine to methionine (K27M) mutation that occurs on H3F3A and HIST1H3B/C, genes encoding histone variants. The K27M mutation disrupts methylation by polycomb repressive complex 2 on histone H3 at lysine 27, leading to global hypomethylation. Histone 3 lysine 27 trimethylation is an important developmental regulator controlling gene expression. This review discusses the developmental and epigenetic mechanisms driving disease progression in DIPG, as well as the profound therapeutic implications of epigenetic programming.

Original languageEnglish (US)
Pages (from-to)195-206
Number of pages12
JournalNeuro-oncology
Volume22
Issue number2
DOIs
StatePublished - Feb 20 2020

Keywords

  • DIPG
  • epigenetics
  • H3 K27M
  • histone variants

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

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    Mendez, F. M., Núñez, F. J., Garcia-Fabiani, M. B., Haase, S., Carney, S., Gauss, J. C., Becher, O. J., Lowenstein, P. R., & Castro, M. G. (2020). Epigenetic reprogramming and chromatin accessibility in pediatric diffuse intrinsic pontine gliomas: A neural developmental disease. Neuro-oncology, 22(2), 195-206. https://doi.org/10.1093/neuonc/noz218