Epigenetics

J. T. Pepin*, H. Cardenas, K. P. Nephew, D. Matei

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Ovarian cancer (OC) is characterized by complex epigenetic alterations, including aberrant DNA methylation, histone modifications, and nucleosome positioning. Advances in the sequencing technologies over the past decade have enabled deeper characterization of the chromatin landscape in cancer. Alterations of the epigenome have been implicated in tumor progression, development of chemotherapy resistance, persistence, and survival of cancer stem cells. As the machinery governing epigenetic changes is being deciphered, the OC epigenome will become an important new therapeutic cancer target.

Original languageEnglish (US)
Title of host publicationTranslational Advances in Gynecologic Cancers
PublisherElsevier Inc
Pages35-58
Number of pages24
ISBN (Electronic)9780128037980
ISBN (Print)9780128037416
DOIs
StatePublished - Feb 22 2017

Keywords

  • DNA methylation
  • Epigenome
  • Histone modifications
  • Ovarian cancer

ASJC Scopus subject areas

  • Medicine(all)

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