Epigenetics

J. T. Pepin; H. Cardenas; K. P. Nephew; D. Matei

doi:10.1016/B978-0-12-803741-6.00003-3

Epigenetics

J. T. Pepin^*, H. Cardenas, K. P. Nephew, D. Matei

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Ovarian cancer (OC) is characterized by complex epigenetic alterations, including aberrant DNA methylation, histone modifications, and nucleosome positioning. Advances in the sequencing technologies over the past decade have enabled deeper characterization of the chromatin landscape in cancer. Alterations of the epigenome have been implicated in tumor progression, development of chemotherapy resistance, persistence, and survival of cancer stem cells. As the machinery governing epigenetic changes is being deciphered, the OC epigenome will become an important new therapeutic cancer target.

Original language	English (US)
Title of host publication	Translational Advances in Gynecologic Cancers
Publisher	Elsevier Inc
Pages	35-58
Number of pages	24
ISBN (Electronic)	9780128037980
ISBN (Print)	9780128037416
DOIs	https://doi.org/10.1016/B978-0-12-803741-6.00003-3
State	Published - Feb 22 2017

Keywords

DNA methylation
Epigenome
Histone modifications
Ovarian cancer

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-803741-6.00003-3

Cite this

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title = "Epigenetics",

abstract = "Ovarian cancer (OC) is characterized by complex epigenetic alterations, including aberrant DNA methylation, histone modifications, and nucleosome positioning. Advances in the sequencing technologies over the past decade have enabled deeper characterization of the chromatin landscape in cancer. Alterations of the epigenome have been implicated in tumor progression, development of chemotherapy resistance, persistence, and survival of cancer stem cells. As the machinery governing epigenetic changes is being deciphered, the OC epigenome will become an important new therapeutic cancer target.",

keywords = "DNA methylation, Epigenome, Histone modifications, Ovarian cancer",

author = "Pepin, {J. T.} and H. Cardenas and Nephew, {K. P.} and D. Matei",

year = "2017",

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doi = "10.1016/B978-0-12-803741-6.00003-3",

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TY - CHAP

T1 - Epigenetics

AU - Pepin, J. T.

AU - Cardenas, H.

AU - Nephew, K. P.

AU - Matei, D.

PY - 2017/2/22

Y1 - 2017/2/22

N2 - Ovarian cancer (OC) is characterized by complex epigenetic alterations, including aberrant DNA methylation, histone modifications, and nucleosome positioning. Advances in the sequencing technologies over the past decade have enabled deeper characterization of the chromatin landscape in cancer. Alterations of the epigenome have been implicated in tumor progression, development of chemotherapy resistance, persistence, and survival of cancer stem cells. As the machinery governing epigenetic changes is being deciphered, the OC epigenome will become an important new therapeutic cancer target.

AB - Ovarian cancer (OC) is characterized by complex epigenetic alterations, including aberrant DNA methylation, histone modifications, and nucleosome positioning. Advances in the sequencing technologies over the past decade have enabled deeper characterization of the chromatin landscape in cancer. Alterations of the epigenome have been implicated in tumor progression, development of chemotherapy resistance, persistence, and survival of cancer stem cells. As the machinery governing epigenetic changes is being deciphered, the OC epigenome will become an important new therapeutic cancer target.

KW - DNA methylation

KW - Epigenome

KW - Histone modifications

KW - Ovarian cancer

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M3 - Chapter

AN - SCOPUS:85027153586

SN - 9780128037416

SP - 35

EP - 58

BT - Translational Advances in Gynecologic Cancers

PB - Elsevier Inc

ER -

Epigenetics

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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