Epithelial adhesion molecules and the regulation of intestinal homeostasis during neutrophil transepithelial migration

Ronen Sumagin*, Charles A. Parkos

*Corresponding author for this work

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Epithelial adhesion molecules play essential roles in regulating cellular function and maintaining mucosal tissue homeostasis. Some form epithelial junctional complexes to provide structural support for epithelial monolayers and act as a selectively permeable barrier separating luminal contents from the surrounding tissue. Others serve as docking structures for invading viruses and bacteria, while also regulating the immune response. They can either obstruct or serve as footholds for the immune cells recruited to mucosal surfaces. Currently, it is well appreciated that adhesion molecules collectively serve as environmental cue sensors and trigger signaling events to regulate epithelial function through their association with the cell cytoskeleton and various intracellular adapter proteins. Immune cells, particularly neutrophils (PMN) during transepithelial migration (TEM), can modulate adhesion molecule expression, conformation, and distribution, significantly impacting epithelial function and tissue homeostasis. This review discusses the roles of key intestinal epithelial adhesion molecules in regulating PMN trafficking and outlines the potential consequences on epithelial function.

Original languageEnglish (US)
JournalTissue Barriers
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Adhesion molecules
  • Barrier
  • Cell migration
  • Epithelial cells
  • Neutrophils

ASJC Scopus subject areas

  • Biochemistry
  • Histology
  • Cell Biology

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