Epithelial cell abnormalities: Squamous

Michael R. Henry; Donna K. Russell; Ronald D. Luff; Marianne U. Prey; Thomas C. Wright; Ritu Nayar

doi:10.1007/978-3-319-11074-5_5

Epithelial cell abnormalities: Squamous

Michael R. Henry^*, Donna K. Russell, Ronald D. Luff, Marianne U. Prey, Thomas C. Wright, Ritu Nayar

^*Corresponding author for this work

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

8 Scopus citations

Abstract

Our understanding of preinvasive HPV-associated squamous lesions supports only two conceptual divisions: HPV infection and true precancer. Transient infections generally regress over the course of 1–2 years, and lesions with HPV persistence are associated with an increased risk of developing a cancer precursor (precancer) or invasive cancer. This concept led to the introduction of the two-tiered nomenclature of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL), by the Bethesda System (TBS) in 1988. The 2014 Bethesda update maintains this dichotomous reporting terminology for the squamous intraepithelial lesions. Since the focus of cervical cancer screening is primarily the detection of HSIL, this chapter has been substantially expanded to include problematic patterns and mimics that may lead to locator and/or interpretation errors of non-neoplastic changes as HSIL/ASC-H or vice versa.

Original language	English (US)
Title of host publication	The Bethesda System for Reporting Cervical Cytology
Subtitle of host publication	Definitions, Criteria, and Explanatory Notes
Publisher	Springer International Publishing
Pages	135-192
Number of pages	58
ISBN (Electronic)	9783319110745
ISBN (Print)	9783319110738
DOIs	https://doi.org/10.1007/978-3-319-11074-5_5
State	Published - Jan 1 2015

Keywords

CIN
Cervix
Cytology
Dysplasia
HSIL
LSIL
Reporting
Squamous
Squamous intraepithelial lesion

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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Epithelial cell abnormalities : Squamous. / Henry, Michael R.; Russell, Donna K.; Luff, Ronald D.; Prey, Marianne U.; Wright, Thomas C.; Nayar, Ritu.

The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes. Springer International Publishing, 2015. p. 135-192.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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