Epithelial cell abnormalities: Squamous

Michael R. Henry*, Donna K. Russell, Ronald D. Luff, Marianne U. Prey, Thomas C. Wright, Ritu Nayar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


Our understanding of preinvasive HPV-associated squamous lesions supports only two conceptual divisions: HPV infection and true precancer. Transient infections generally regress over the course of 1–2 years, and lesions with HPV persistence are associated with an increased risk of developing a cancer precursor (precancer) or invasive cancer. This concept led to the introduction of the two-tiered nomenclature of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL), by the Bethesda System (TBS) in 1988. The 2014 Bethesda update maintains this dichotomous reporting terminology for the squamous intraepithelial lesions. Since the focus of cervical cancer screening is primarily the detection of HSIL, this chapter has been substantially expanded to include problematic patterns and mimics that may lead to locator and/or interpretation errors of non-neoplastic changes as HSIL/ASC-H or vice versa.

Original languageEnglish (US)
Title of host publicationThe Bethesda System for Reporting Cervical Cytology
Subtitle of host publicationDefinitions, Criteria, and Explanatory Notes
PublisherSpringer International Publishing
Number of pages58
ISBN (Electronic)9783319110745
ISBN (Print)9783319110738
StatePublished - Jan 1 2015


  • CIN
  • Cervix
  • Cytology
  • Dysplasia
  • HSIL
  • LSIL
  • Reporting
  • Squamous
  • Squamous intraepithelial lesion

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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