Epithelial-mesenchymal transition and its implications for fibrosis

Raghu Kalluri*, Eric G. Neilson

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1918 Scopus citations

Abstract

Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more than a third of all disease-related fibroblasts originate from tubular epithelia at the site of injury. This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.

Original languageEnglish (US)
Pages (from-to)1776-1784
Number of pages9
JournalJournal of Clinical Investigation
Volume112
Issue number12
DOIs
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Medicine(all)

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