Epithelium: At the interface of innate and adaptive immune responses

Robert P. Schleimer*, Atsushi Kato, Robert Kern, Douglas Kuperman, Pedro C. Avila

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

264 Scopus citations

Abstract

Several diseases of the airways have a strong component of allergic inflammation in their cause, including allergic rhinitis, asthma, polypoid chronic rhinosinusitis, eosinophilic bronchitis, and others. Although the roles played by antigens and pathogens vary, these diseases have in common a pathology that includes marked activation of epithelial cells in the upper airways, the lower airways, or both. Substantial new evidence indicates an important role of epithelial cells as both mediators and regulators of innate immune responses and adaptive immune responses, as well as the transition from innate immunity to adaptive immunity. The purpose of this review is to discuss recent studies that bear on the molecular and cellular mechanisms by which epithelial cells help to shape the responses of dendritic cells, T cells, and B cells and inflammatory cell recruitment in the context of human disease. Evidence will be discussed that suggests that secreted products of epithelial cells and molecules expressed on their cell surfaces can profoundly influence both immunity and inflammation in the airways.

Original languageEnglish (US)
Pages (from-to)1279-1284
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Volume120
Issue number6
DOIs
StatePublished - Dec 2007

Keywords

  • Epithelium
  • adaptive immunity
  • airway inflammation
  • immune regulation
  • innate immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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