Abstract
Injection of responder mice with poly(Glu60Ala30Tyr10) (GAT) followed by immunization with GAT-methylated bovine serum albumin (GATMBSA) selectively suppresses anti-MBSA plaque-forming cell (PFC) and delayed hypersensitivity (DTH) reactions. Conversely, MBSA injection followed by GATMBSA immunization suppresses anti-GAT PFC and DTH, while anti-MBSA responses remain intact. Suppression occurs for doses of antigen which are optimally immunogenic. The suppression is specific and does not act in a bystander fashion. These results demonstrate that epitope-specific regulation is reciprocal, is not limited to humoral responses, and is not imited to molecules of low molecular weight.
Original language | English (US) |
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Pages (from-to) | 375-385 |
Number of pages | 11 |
Journal | Cellular Immunology |
Volume | 98 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1 1986 |
ASJC Scopus subject areas
- Immunology