Epitope-specific regulation in Ir gene systems. I. Conditions for the induction of epitope-specific suppressors to poly(Glu60Ala30Tyr10)

Lizhe Sun; Carl Waltenbaugh

doi:10.1016/0008-8749(86)90297-2

Epitope-specific regulation in Ir gene systems. I. Conditions for the induction of epitope-specific suppressors to poly(Glu⁶⁰Ala³⁰Tyr¹⁰)

Lizhe Sun^*, Carl Waltenbaugh

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Injection of responder mice with poly(Glu⁶⁰Ala³⁰Tyr¹⁰) (GAT) followed by immunization with GAT-methylated bovine serum albumin (GATMBSA) selectively suppresses anti-MBSA plaque-forming cell (PFC) and delayed hypersensitivity (DTH) reactions. Conversely, MBSA injection followed by GATMBSA immunization suppresses anti-GAT PFC and DTH, while anti-MBSA responses remain intact. Suppression occurs for doses of antigen which are optimally immunogenic. The suppression is specific and does not act in a bystander fashion. These results demonstrate that epitope-specific regulation is reciprocal, is not limited to humoral responses, and is not imited to molecules of low molecular weight.

Original language	English (US)
Pages (from-to)	375-385
Number of pages	11
Journal	Cellular Immunology
Volume	98
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(86)90297-2
State	Published - Apr 1 1986

Funding

’ This work was supported by United States Public Institutes of Health and CA-34109 from the National

ASJC Scopus subject areas

Immunology

Access to Document

10.1016/0008-8749(86)90297-2

Cite this

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title = "Epitope-specific regulation in Ir gene systems. I. Conditions for the induction of epitope-specific suppressors to poly(Glu60Ala30Tyr10)",

abstract = "Injection of responder mice with poly(Glu60Ala30Tyr10) (GAT) followed by immunization with GAT-methylated bovine serum albumin (GATMBSA) selectively suppresses anti-MBSA plaque-forming cell (PFC) and delayed hypersensitivity (DTH) reactions. Conversely, MBSA injection followed by GATMBSA immunization suppresses anti-GAT PFC and DTH, while anti-MBSA responses remain intact. Suppression occurs for doses of antigen which are optimally immunogenic. The suppression is specific and does not act in a bystander fashion. These results demonstrate that epitope-specific regulation is reciprocal, is not limited to humoral responses, and is not imited to molecules of low molecular weight.",

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AU - Sun, Lizhe

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AB - Injection of responder mice with poly(Glu60Ala30Tyr10) (GAT) followed by immunization with GAT-methylated bovine serum albumin (GATMBSA) selectively suppresses anti-MBSA plaque-forming cell (PFC) and delayed hypersensitivity (DTH) reactions. Conversely, MBSA injection followed by GATMBSA immunization suppresses anti-GAT PFC and DTH, while anti-MBSA responses remain intact. Suppression occurs for doses of antigen which are optimally immunogenic. The suppression is specific and does not act in a bystander fashion. These results demonstrate that epitope-specific regulation is reciprocal, is not limited to humoral responses, and is not imited to molecules of low molecular weight.

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