Epitope spreading

Carol J. Vanderlugt, Stephen D. Miller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

300 Scopus citations


Epitope (determinant) spreading is the development of immune responses to endogenous epitopes secondary to the release of self antigens during a chronic autoimmune or inflammatory response. The past year has seen considerable advances in our understanding of the contribution of epitope spreading to the chronic pathogenesis of experimental T-cell-mediated and antibody-mediated autoimmune diseases. Most significantly, conclusive functional evidence for a major role for epitope spreading in the chronic pathogenesis of murine relapsing-remitting experimental autoimmune encephalomyelitis, a CD4+ T-cell-mediated model of multiple sclerosis, was forthcoming.

Original languageEnglish (US)
Pages (from-to)831-836
Number of pages6
JournalCurrent Opinion in Immunology
Issue number6
StatePublished - Dec 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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