Evidence continues to accumulate supporting the hypothesis that tissue damage during an immune response can lead to the priming of self-reactive T and/or B lymphocytes, regardless of the specificity of the initial insult. This review will focus primarily on epitope spreading at the T-cell level. Understanding the cellular and molecular basis of epitope spreading in various chronic immune-mediated human diseases and their animal models is crucial to understanding the pathogenesis of these diseases and to the ultimate goal of designing antigen-specific treatments.
|Original language||English (US)|
|Number of pages||11|
|Journal||Nature Reviews Immunology|
|State||Published - Feb 2002|
ASJC Scopus subject areas
- Immunology and Allergy