Epitope spreading in immune-mediated diseases: Implications for immunotherapy

Carol L. Vanderlugt, Stephen D. Miller*

*Corresponding author for this work

Research output: Contribution to journalReview article

564 Scopus citations

Abstract

Evidence continues to accumulate supporting the hypothesis that tissue damage during an immune response can lead to the priming of self-reactive T and/or B lymphocytes, regardless of the specificity of the initial insult. This review will focus primarily on epitope spreading at the T-cell level. Understanding the cellular and molecular basis of epitope spreading in various chronic immune-mediated human diseases and their animal models is crucial to understanding the pathogenesis of these diseases and to the ultimate goal of designing antigen-specific treatments.

Original languageEnglish (US)
Pages (from-to)85-95
Number of pages11
JournalNature Reviews Immunology
Volume2
Issue number2
DOIs
StatePublished - Feb 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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