EPR spectroscopy of MolB2C2-A reveals mechanism of transport for a bacterial type II molybdate importer

Austin J. Rice, Frances J.D. Alvarez, Kathryn M. Schultz, Candice S. Klug, Amy L. Davidson, Heather W. Pinkett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Background: ABC importers utilize the energy of ATP hydrolysis to transport substrates into the cell. Results: EPR studies show how three transmembrane gates of MolB2C2-A work in concert to allow substrate to enter the cytoplasm. Conclusion: The movements of these gates indicate an opening and closing limited to small substrates. Significance: This model sheds light on how small nutrients are transported across the membrane.

Original languageEnglish (US)
Pages (from-to)21228-21235
Number of pages8
JournalJournal of Biological Chemistry
Volume288
Issue number29
DOIs
StatePublished - Jul 19 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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