Epstein-Barr virus-associated inflammatory pseudotumor presenting as a colonic mass

Shunyou Gong, Iwona Auer, Rajan Duggal, Stefania Pittaluga, Mark Raffeld, Elaine S. Jaffe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Epstein-Barr virus (EBV)-positive inflammatory pseudotumor (IPT) commonly involves spleen and liver and has only rarely been reported in the gastrointestinal (GI) tract. The spindle cells may express myofibroblastic or follicular dendritic cell markers. We report a challenging case of EBV-positive IPT arising in the ascending colon. The lesion was composed of spindle cells positive for smooth muscle actin but negative for all follicular dendritic cell markers tested and was associated with an exuberant lymphoid proliferation containing reactive follicles, abundant plasma cells, and small lymphocytes. We further discuss pitfalls for possible misdiagnosis as ALK-positive inflammatory myofibroblastic tumor, IgG4-related disease, and peripheral T-cell lymphoma. Our case represents the first EBV-positive inflammatory pseudotumor of the GI tract in the Western literature. Awareness of this rare entity in GI tract is essential for correct diagnosis and appropriate patient management.

Original languageEnglish (US)
Pages (from-to)1956-1961
Number of pages6
JournalHuman pathology
Issue number12
StatePublished - Dec 2015


  • Epstein-Barr virus
  • Gastrointestinal tract
  • Inflammatory pseudotumor
  • Inflammatory pseudotumor-like follicular dendritic cell tumor
  • Myofibroblasts

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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