Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor

Keith M. Haan, William W. Kwok, Richard Longnecker*, Peter Speck

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


Epstein-Barr virus (EBV) glycoprotein gp350/gp220 association with cellular CD21 facilitates virion attachment to B lymphocytes. Membrane fusion requires the additional interaction between virion gp42 and cellular HLA-DR. This binding is thought to catalyze membrane fusion through a further association with the gp85-gp25 (gH-gL) complex. Cell lines expressing CD21 but lacking expression of HLA class II molecules are resistant to infection by a recombinant EBV expressing enhanced green fluorescent protein. Surface expression of HLA-DR, HLA-DP, or HLA-DQ confers susceptibilitY to EBV infection on resistant cells that express CD21. Therefore, HLA-DP or HLA-DQ can substitute for HLA-DR and serve as a coreceptor in EBV entry.

Original languageEnglish (US)
Pages (from-to)2451-2454
Number of pages4
JournalJournal of virology
Issue number5
StatePublished - 2000

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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