Abstract
Epstein-Barr virus (EBV) glycoprotein gp350/gp220 association with cellular CD21 facilitates virion attachment to B lymphocytes. Membrane fusion requires the additional interaction between virion gp42 and cellular HLA-DR. This binding is thought to catalyze membrane fusion through a further association with the gp85-gp25 (gH-gL) complex. Cell lines expressing CD21 but lacking expression of HLA class II molecules are resistant to infection by a recombinant EBV expressing enhanced green fluorescent protein. Surface expression of HLA-DR, HLA-DP, or HLA-DQ confers susceptibilitY to EBV infection on resistant cells that express CD21. Therefore, HLA-DP or HLA-DQ can substitute for HLA-DR and serve as a coreceptor in EBV entry.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2451-2454 |
| Number of pages | 4 |
| Journal | Journal of virology |
| Volume | 74 |
| Issue number | 5 |
| DOIs | |
| State | Published - 2000 |
ASJC Scopus subject areas
- Insect Science
- Virology
- Microbiology
- Immunology