Epstein-Barr virus in Burkitt's lymphoma: A role for latent membrane protein 2A

Kathryn T. Bieging; Michelle Swanson-Mungerson; Alexandra C. Amick; Richard Longnecker

doi:10.4161/cc.9.5.10840

Epstein-Barr virus in Burkitt's lymphoma: A role for latent membrane protein 2A

Kathryn T. Bieging, Michelle Swanson-Mungerson, Alexandra C. Amick, Richard Longnecker^*

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Burkitt's lymphoma (BL) is characterized by translocation of the MYC gene to an immunoglobulin locus. Transgenic mouse models have been used to study the molecular changes that are necessary to bypass tumor suppression in the presence of translocated MYC. Inactivation of the p53 pathway is a major step to tumor formation in mouse models that is also seen in human disease. Human BL is often highly associated with Epstein-Barr virus (EBV). The EBV latency protein latent membrane protein 2A (LMP2A) is known to promote B cell survival by affecting levels of pro-survival factors. Using LMP2A transgenic mouse models, we have identified a novel mechanism that permits lymphomagenesis in the presence of an intact p53 pathway. This work uncovers a contribution of EBV to molecular events that have documented importance in BL pathogenesis, and may underlie the poorly understood link between EBV and BL.

Original language	English (US)
Pages (from-to)	901-908
Number of pages	8
Journal	Cell Cycle
Volume	9
Issue number	5
DOIs	https://doi.org/10.4161/cc.9.5.10840
State	Published - Mar 1 2010

Keywords

Apoptosis
Burkitt's lymphoma
Epstein-Barr virus
LMP2A
Myc
Viral oncogenesis
p53

ASJC Scopus subject areas

Molecular Biology
Cell Biology
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cc.9.5.10840

Cite this

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title = "Epstein-Barr virus in Burkitt's lymphoma: A role for latent membrane protein 2A",

abstract = "Burkitt's lymphoma (BL) is characterized by translocation of the MYC gene to an immunoglobulin locus. Transgenic mouse models have been used to study the molecular changes that are necessary to bypass tumor suppression in the presence of translocated MYC. Inactivation of the p53 pathway is a major step to tumor formation in mouse models that is also seen in human disease. Human BL is often highly associated with Epstein-Barr virus (EBV). The EBV latency protein latent membrane protein 2A (LMP2A) is known to promote B cell survival by affecting levels of pro-survival factors. Using LMP2A transgenic mouse models, we have identified a novel mechanism that permits lymphomagenesis in the presence of an intact p53 pathway. This work uncovers a contribution of EBV to molecular events that have documented importance in BL pathogenesis, and may underlie the poorly understood link between EBV and BL.",

keywords = "Apoptosis, Burkitt's lymphoma, Epstein-Barr virus, LMP2A, Myc, Viral oncogenesis, p53",

author = "Bieging, {Kathryn T.} and Michelle Swanson-Mungerson and Amick, {Alexandra C.} and Richard Longnecker",

note = "Funding Information: R.L. is supported by the Public Health Service grants CA021776, CA73507, CA117794, CA133063, AI067048 and AI076183 from the National Cancer Institute and National Institute of Allergy and Infectious Disease. K.B. was supported by NIH/NCI training grant T32CA009560. We would like to thank current and former members of the Longnecker laboratory for their contributions to the work described, as well as our many colleagues throughout the world whose work also has contributed to the understanding of the contribution of EBV to Burkitt{\textquoteright}s Lymphoma.",

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doi = "10.4161/cc.9.5.10840",

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AU - Longnecker, Richard

N1 - Funding Information: R.L. is supported by the Public Health Service grants CA021776, CA73507, CA117794, CA133063, AI067048 and AI076183 from the National Cancer Institute and National Institute of Allergy and Infectious Disease. K.B. was supported by NIH/NCI training grant T32CA009560. We would like to thank current and former members of the Longnecker laboratory for their contributions to the work described, as well as our many colleagues throughout the world whose work also has contributed to the understanding of the contribution of EBV to Burkitt’s Lymphoma.

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N2 - Burkitt's lymphoma (BL) is characterized by translocation of the MYC gene to an immunoglobulin locus. Transgenic mouse models have been used to study the molecular changes that are necessary to bypass tumor suppression in the presence of translocated MYC. Inactivation of the p53 pathway is a major step to tumor formation in mouse models that is also seen in human disease. Human BL is often highly associated with Epstein-Barr virus (EBV). The EBV latency protein latent membrane protein 2A (LMP2A) is known to promote B cell survival by affecting levels of pro-survival factors. Using LMP2A transgenic mouse models, we have identified a novel mechanism that permits lymphomagenesis in the presence of an intact p53 pathway. This work uncovers a contribution of EBV to molecular events that have documented importance in BL pathogenesis, and may underlie the poorly understood link between EBV and BL.

AB - Burkitt's lymphoma (BL) is characterized by translocation of the MYC gene to an immunoglobulin locus. Transgenic mouse models have been used to study the molecular changes that are necessary to bypass tumor suppression in the presence of translocated MYC. Inactivation of the p53 pathway is a major step to tumor formation in mouse models that is also seen in human disease. Human BL is often highly associated with Epstein-Barr virus (EBV). The EBV latency protein latent membrane protein 2A (LMP2A) is known to promote B cell survival by affecting levels of pro-survival factors. Using LMP2A transgenic mouse models, we have identified a novel mechanism that permits lymphomagenesis in the presence of an intact p53 pathway. This work uncovers a contribution of EBV to molecular events that have documented importance in BL pathogenesis, and may underlie the poorly understood link between EBV and BL.

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Epstein-Barr virus in Burkitt's lymphoma: A role for latent membrane protein 2A

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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